grant
Molecular Mechanisms of Non-muscle Myosin II Contractility
NIHUS FederalResearch GrantFY2026ATP phosphohydrolaseATPaseAcetylationActinsAdenosine TriphosphataseAffectBehaviorBindingBinding ProteinsBiochemicalCell Communication and SignalingCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular biologyCephalicCranialDataDeacetylationDevelopmentDiseaseDisorderDrosophilaDrosophila genusEnzyme GeneEnzymesFaceFilamentGeneHomologGenerationsGeneticGoalsHomologHomologous GeneHomologueHumanImmune responseIntracellular Communication and SignalingLigand Binding ProteinLigand Binding Protein GeneLightMicro-tubuleMicroscopyMicrotubulesModelingModern ManMolecularMolecular InteractionMolecular MotorsMotorMyosin IIMyosin Type IINervous System DiseasesNervous System DisorderNeural Crest CellNeurologic DisordersNeurological DisordersPathologyPhosphorylationPhotoradiationPlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProtein BindingProtein ModificationProtein PhosphorylationProteinsRegulationResearchRoleSeriesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessTailWorkbiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbound proteincardiovascular healthcell biologycell motilitycellular pathologydevelopmentaldimerexperimentexperimental researchexperimental studyexperimentsfacesfacialfruit flyhigh definitionhigh-resolutionhost responseimmune system responseimmunoresponseinsightneurological diseasenon-muscle myosinnonmuscle myosinnovelprotein crosslinksocial roletool
Description preview
PROJECT SUMMARY/ABSTRACT
Non-muscle myosin II (NMII) contractility is critical to number cellular processes from development to disease.
NMII is an ATP-dependent molecular motor that functions as a dimer composed of two heavy chains, which are
made of an ATPase/motor domain that binds actin and a coiled-coil tail domain. It is also bound to two…
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