grant
Molecular Mechanisms of Myoblast Fusion
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025Actin FilamentsActinsAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAdhesion MoleculeBindingBiochemistryBiologic ModelsBiological ChemistryBiological ModelsBiologyBiophysicsBrachydanio rerioBundlingCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell CycleCell Division CycleCell NucleusCell fusionCell membraneCellsCellular MatrixCellular biologyCicatrixComplexCoupledCultured CellsCytoplasmCytoplasmic MembraneCytoskeletal SystemCytoskeletonDNA Molecular BiologyDanio rerioDataDegenerative DisorderDevelopmentDiseaseDisorderDrosophilaDrosophila genusE3 LigaseE3 Ubiquitin LigaseEmbryoEmbryonicEmbryonic Muscle CellsF-ActinFamilyFilamentous ActinGTP BindingGTP PhosphohydrolasesGTP boundGTPasesGeneticGrantGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHealthHumanIn VitroInvadedLifeMechanicsMediatingMembraneMembrane FusionMicrofilamentsModel SystemModern ManMolecularMolecular BiologyMolecular InteractionMuscleMuscle DevelopmentMuscle DiseaseMuscle DisordersMuscle FibersMuscle TissueMuscular DevelopmentMuscular DiseasesMyoblastsMyofilamentsMyopathic ConditionsMyopathic Diseases and SyndromesMyopathic disease or syndromeMyopathyMyotubesNatural regenerationNucleusPhasePhysical condensationPlasma MembranePlayPolymersPrecursor Muscle CellsProcessProteinsRegenerationRegulationReportingRhabdomyocyteRoleSH3 DomainsSRC Homology Region 3 DomainScarsSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesStructureSynapsesSynapticTestingTherapeuticUbiquitilationUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationVoluntary MuscleWorkZebra DanioZebra FishZebrafishadapter proteinanillinbiophysical foundationbiophysical principlesbiophysical sciencescell adhesion proteincell biologycondensationcongenital myopathydegenerative conditiondegenerative diseasedevelopmentaldriving forcefruit flyguanosinetriphosphatasein vivoinsightintracellular skeletonmechanicmechanicalmembermembrane structuremuscle progenitormuscle progenitor cellmuscle regenerationmuscle stem cellmuscularmuscular disordermutantnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachplasmalemmapolymerpolymericpolymerizationpostmitoticpreventpreventingrecruitregenerateresponsesocial rolesynapseubiquinationubiquitin conjugationubiquitin-protein ligase
Description preview
PROJECT SUMMARY
Myoblast fusion, during which mononucleated myoblasts fuse to form multinucleate, contractile muscle fibers, is
essential for skeletal muscle development and regeneration. Certain congenital myopathies are characterized
by minute myofibers, suggesting that myoblast fusion may be compromised in these conditions. Thus,
investigating…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click