grant
Molecular Mechanisms of Hair Bundle Development and Maintenance
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Jul 2020Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026ATP phosphohydrolaseATPaseActin FilamentsActin-Activated ATPaseActinsAdenosine TriphosphataseAffectArchitectureAssayAuditoryBackBioassayBiochemicalBiological AssayCartoonsCell BodyCell LineCellLineCellsCellular MechanotransductionCharacteristicsCochleaCochlear OrganComplexCorti CellCytoplasmic OrganelleCytosolDNA mutationDataDetectionDevelopmentDimensionsDorsumEarElectron MicroscopyEngineering / ArchitectureExhibitsFrequenciesFundingFutureGeneralized GrowthGeneticGenetic ChangeGenetic defectGenetic mutationGrowthHairHair CellsHearingHearing LossHeightHumanHypoacusesHypoacusisImaging ProceduresImaging TechnicsImaging TechniquesIn VitroIndividualInner Hair CellsInner ear hair cellsIsoformsLength of LifeLinkLocomotor ActivityLongevityMaintenanceMechanical Signal TransductionMechanosensory TransductionMicrofilamentsMitochondriaModern ManMolecularMotorMotor ActivityMovementMutationMyofilamentsMyosin AMyosin ATPaseMyosin Adenosine TriphosphataseMyosin AdenosinetriphosphataseMyosin IIAMyosinsN-terminalNH2-terminalNon-Muscle Myosin Type IIANonmuscle Myosin Type IIAPathogenicityPathologicPathologyPolymersPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessPropertyProtein IsoformsProtein ModificationProteinsProteolytic ClippingProteolytic ProcessingProteolytic RegulationPublishingRegulationRegulation of ProteolysisRodentRodentiaRodents MammalsRoleSensoryShapesStrains Cell LinesStructureTestingTissue GrowthWorkbody movementcultured cell linedeafnessdevelopmentaldysfunctional hearingear hair cellexperimentexperimental researchexperimental studyexperimentsfluorescence imagingfluorescent imaginggenetic hearing impairmentgenetic hearing lossgenome mutationgood hearinghealthy hearinghearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmenthereditary hearing impairmenthereditary hearing lossinherited hearing impairmentinherited hearing lossmechanosensingmechanotransductionmicroscope imagingmicroscopic imagingmicroscopy imagingmitochondrialmonomermouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnormal hearingnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenypolymerpolymericpolymerizationpostnatalpreventpreventingprofound disabilityprotein purificationreconstitutereconstitutionresponseserious disabilitysevere disabilitysingle moleculesocial rolesoundtrafficking
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Project Summary
Cochlear hair cells detect sound by sensing the movement of mechanosensitive actin-based projections, known
as stereocilia. Disruption to these delicate mechanosensors is a common pathology found in multiple forms of
hearing loss. A central molecule needed for the assembly of stereocilia is myosin 15 (MYO15A), a motor protein
that…
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