grant
Molecular Mechanisms of Chromatin Remodeling and Deacetylation
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 Mar 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026ATP HydrolysisATP phosphohydrolaseATPaseAdenosine TriphosphataseAssayBioassayBiochemicalBiological AssayBiologyCancersChromatinChromatin StructureComplexCoupledCryo-electron MicroscopyCryoelectron MicroscopyDNADataDeacetylaseDeacetylationDeoxyribonucleic AcidDiseaseDisorderDysfunctionElectron CryomicroscopyEnzyme GeneEnzymesEssential GenesFRETFamilyFluorescence Resonance Energy TransferFunctional disorderFörster Resonance Energy TransferGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenetic TranscriptionGenome StabilityGenomic StabilityHDACHDAC ProteinsHistone DeacetylaseHistone DeacetylationHistonesISWIISWI proteinImitation SwitchIndividualInvestigationLaboratoriesLinkMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMethodologyMolecularMolecular Dynamics SimulationNatureNerve DegenerationNeuron DegenerationNucleosomesPathway interactionsPhysiopathologyPlayPositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProtein ModificationRNA ExpressionRegulationResearchRoleSilent Mating Type Information Regulator 2-like ProteinsSir2-like ProteinsSirtuinsSiteSubstrate SpecificityTimeTranscriptionWorkchromatin remodelingcrosslinkcryo-EMcryoEMcryogenic electron microscopydevelopmental diseasedevelopmental disorderdisease preventiondisorder preventioneffective therapyeffective treatmentgenome integritygenomic integrityhigh definitionhigh-resolutionhistone modificationinnovateinnovationinnovativeinsightmalignancymolecular dynamicsneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationpathophysiologypathwayprogramspublic health relevancerepairrepairedsocial rolesupport networktherapeutic agent developmenttherapeutic developmenttooltreatment strategy
Description preview
Project Summary
Chromatin structure and function are dynamically regulated by ATP-dependent chromatin remodelers and Sirtuin
histone deacetylases, two critical enzyme families that play pivotal roles in DNA transcription, replication, repair,
and genome stability. Chromatin remodelers use ATP hydrolysis to reposition and modify nucleosomes, while…
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