grant
Molecular Mechanisms Governing Non-canonical miR-146a Biogenesis
Organization BECKMAN RESEARCH INSTITUTE/CITY OF HOPELocation DUARTE, UNITED STATESPosted 5 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AC GlobulinAffectAmino Acyl T RNA SynthetasesAmino Acyl-tRNA LigasesAmino Acyl-tRNA SynthetasesAminoacyl Transfer RNA SynthetaseAminoacyl-tRNA SynthetaseAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApicalAutoimmune DiseasesAutoregulationBindingBinding ProteinsBiochemicalBiogenesisBlood Coagulation Factor VBlood DiseasesBone marrow failureCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancersCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCicloheximideCoagulation Factor VCoupledCycloheximideDependenceDevelopmentDiseaseDisorderDysmyelopoietic SyndromesEPRS enzymeElementsEventFactor PiFactor VFeedbackFunctional RNAGenesHematologic CancerHematologic DiseasesHematologic MalignanciesHematologic NeoplasmsHematological DiseaseHematological DisorderHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHomeostasisHumanImmuneImmune Cell ActivationImmune PrecipitationImmunesImmunomodulationImmunoprecipitationImpairmentIn VitroInflammationInflammatoryInflammatory ResponseIntracellular Communication and SignalingLigand Binding ProteinLigand Binding Protein GeneLinkMalignant Hematologic NeoplasmMalignant NeoplasmsMalignant TumorMammaliaMammalsMediatingMethodologyMiceMice MammalsMicroRNAsModern ManMolecularMolecular AnalysisMolecular InteractionMurineMusMyelodysplastic DiseaseMyelodysplastic SyndromesNon-Polyadenylated RNANoncoding RNANontranslated RNAOrigin of LifePathway interactionsPatientsPersonsPhosphorylationPhysiological HomeostasisPlayPost-Transcriptional ControlPost-Transcriptional RegulationProaccelerinProcessProductionProtein BindingProtein BiosynthesisProtein PhosphorylationProteinsProteomicsRNARNA Gene ProductsRecombinantsRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsRegulationReporterResearchResolutionRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSignal TransductionSignal Transduction SystemsSignalingSmoldering LeukemiaStrains Cell LinesTechnologyTestingTherapeuticTranscriptTransfer RNA AcylationTransfer RNA Amino AcylationTransfer RNA AminoacylationTransfer RNA ChargingTransfer RNA SynthetaseTranslational InhibitionTranslational RepressionTranslationsUntranslated RNAVariantVariationWorkaminoacid tRNA ligaseautoimmune attackautoimmune conditionautoimmune destructionautoimmune disorderautoimmune pathogenesisautoimmunity diseasebiological signal transductionblood disorderbound proteincartilage link proteinclinical significanceclinically significantclustered regularly interspaced short palindromic repeats screencultured cell linedevelopmentaleffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentsgenome scalegenome-widegenomewideglutamyl-prolyl-tRNA synthetaseimmune activationimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryinnovateinnovationinnovativelabile componentlabile factorlink proteinloss of functionmalignancymiR therapymiR-based therapeuticmiR-based therapymiRNAmiRNA therapymiRNA-based therapeuticmiRNA-based therapymicroRNA therapymicroRNA-based therapeuticmicroRNA-based therapymyelodysplasianeoplasm/cancernoncodingnovelpathwaypharmacologicpost-transcriptional gene regulationposttranscriptionalprotein synthesisresolutionsscaffoldscaffoldingsensorsocial rolesystemic autoimmunitytRNA AcylationtRNA Amino AcylationtRNA AminoacylationtRNA ChargingtRNA Synthetasetherapeutic miRNAtherapeutic miRstherapeutic microRNAtranslation
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Description preview
Aberrant inflammation drives the development of autoimmune diseases and cancer. The incomplete
understanding of molecular mechanisms controlling inflammatory activation and resolution remains a significant
obstacle to developing effective treatments for inflammatory disorders. Therefore, the main objective of this
proposal is to identify and…
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