grant
Molecular mechanisms by which S. aureus alpha-toxin impairs the antigen-specific T cell response
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldActive ImmunizationActive vaccinationAdultAdult HumanAntibody titer measurementAntigen PresentationAntigen-Presenting CellsAntigensBacterial InfectionsBiologic ModelsBiological ModelsBlood SerumBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell Communication and SignalingCell CompartmentationCell CompartmentationsCell DifferentiationCell Differentiation processCell FunctionCell Mediated ImmunologyCell PhysiologyCell ProcessCell SignalingCell-Mediated ImmunityCellsCellular FunctionCellular ImmunityCellular PhysiologyCellular ProcessCellular biologyCessation of lifeChildChild YouthChildren (0-21)ClinicalClinical ResearchClinical StudyClinical TrialsComplexConsensusCytotoxinDataDeathDefectDevelopmentDiseaseDisorderDrug resistanceEconomic BurdenEconomicsEnsureEpidemiologyEventExhibitsExposure toFoundationsGenerationsGenomeGoalsHumanImmune responseImmunityImmunochemical ImmunologicImmunologicImmunologic SubtypingImmunologicalImmunologicallyImmunologicsImmunophenotypingImpairmentIndividualInfectionInfectious Skin DiseasesInjuryInternationalIntoxicationIntracellular Communication and SignalingKineticsKnowledgeLifeLightLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMHC ReceptorMajor Histocompatibility Complex ReceptorMediatingMembrane PotentialsMemoryMiceMice MammalsModel SystemModern ManMolecularMorbidityMurineMusOutcomePassive ImmunizationPathogenesisPathogenicity FactorsPediatric cohortPhotoradiationPneumoniaPopulationPositionPositioning AttributePredispositionProductionReceptor Mediated Signal TransductionReceptor ProteinRecurrenceRecurrentResearchResting PotentialsRoleS aureusS. aureusS. aureus infectionSepsisSeriesSerumSignal TransductionSignal Transduction SystemsSignalingSiteSkinStaph aureusStaph aureus infectionStaphylococcus aureusStaphylococcus aureus infectionSubcellular ProcessSusceptibilityT cell responseT memory cellT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTissuesToxinTransmembrane PotentialsVaccinationVaccine DesignVaccinesVariantVariationVirulence Factorsaccessory cellactivate T cellsadaptive immune responseadaptive immunityadulthoodanti-microbialantibody titeringantigen-specific T cellsantimicrobialbacteria infectionbacterial diseasebiobankbiological signal transductionbiorepositorycell biologycell typecellular differentiationchild patientsclinical relevanceclinically relevantcutaneous infectioncytokinedeliver vaccinesdesigndesigningdevelop a vaccinedevelop therapydevelop vaccinesdevelopment of a vaccinedevelopmentaldisease modeldisorder modeldraining lymph nodedrug resistanteconomicepidemiologicepidemiologicalfallsgenetic resourcehost responsehuman pathogenimmune system responseimmunogenimmunoresponsein vivoinfected skininfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureusinfection recurrenceinjuriesinsightintervention developmentkidslife spanlifespanlymph glandlymph nodeslymphnodesmemory T lymphocytemortalitymouse modelmurine modelnew approachesnovelnovel approachesnovel strategiesnovel strategypassive vaccinationpediatric patientspre-clinical studypreclinical studypreventpreventingreceptorreceptor-mediated signalingrecurrent infectionrecurring infectionregional lymph noderesistance to Drugresistant to Drugresponseskin infectionsocial roletherapy developmentthymus derived lymphocytetraffickingtreatment developmentvaccine candidatevaccine deliveryvaccine developmentvaccine failureyoungsterα-Toxin
Description preview
PROJECT SUMMARY
Staphylococcus aureus infection in otherwise healthy adults and children is a significant cause of morbidity,
mortality, and economic loss. Recurrence of infection is common, highlighting the fact that S. aureus subverts
the development of protective immunity. The development of a vaccine to prevent S. aureus infection has been
a…
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