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Molecular mechanism of the piRNA biogenesis

Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 6 Jun 2011Deadline 30 Jun 2025 ⚠️
NIHUS FederalResearch GrantFY2025AdoptedAffectAgingAnimalsAnti-viral ResponseArginineBindingBiogenesisBiomedical ResearchCancersCell Communication and SignalingCell LineCell NucleusCell SignalingCell membraneCellLineChromatinComplexCytoplasmCytoplasmic MembraneDNA Transposable ElementsDepositDepositionDevelopmentDiseaseDisorderDrosophilaDrosophila genusEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEnvironmentEukaryotic CellFailureFecundabilityFecundityFertilityFliesFunctional RNAFutureGametesGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGenomeGenome StabilityGenomic SegmentGenomic StabilityGenomicsGerm CellsGerm LinesGerm-Line CellsHealthHistone CodeIn VitroIntracellular Communication and SignalingInvestigationL-ArginineLinkLiquid substanceMaintenanceMalignant NeoplasmsMalignant TumorMediatingMembraneMethylationMiceMice MammalsMicroRNAsModelingModificationMolecularMolecular InteractionMothersMurineMusNon-Polyadenylated RNANoncoding RNANontranslated RNANucleusOogenesisOrganellesOrigin of LifeParasitesPathway interactionsPhasePhysical condensationPlasma MembranePlayPost-Transcriptional Gene SilencingPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProductionProtein FamilyProtein ModificationProtein RegionProteinsRNARNA ExpressionRNA Gene ProductsRNA InterferenceRNA SilencingRNAiRegulationRepressionReproductive CellsResearchRestRibonucleic AcidRoleScaffolding ProteinSequence-Specific Posttranscriptional Gene SilencingSex CellShort interfering RNASignal TransductionSignal Transduction SystemsSignalingSmall Interfering RNASpecific qualifier valueSpecifiedSterilityStrains Cell LinesSystemTherapeuticTranscriptTranscriptionTransmissionTransposable ElementsUntranslated RNAWorkbiological signal transductioncondensationcultured cell linedevelopmentaleggfluidflyfruit flygene locusgenetic locusgenome segmentgenomic locationgenomic locusgenomic regioninitial cellliquidmalignancymembermembrane structuremiRNAneoplasm/cancernoncodingpathwaypiRNApiwi RNAplasmalemmarecruitsex determinationsexual cellsiRNAsocial rolesteriletooltransmission process

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Project title: Molecular mechanism of piRNA biogenesis
Project summary
Non-coding RNAs have diverse functions in eukaryotic cells. Use of these non-coding RNAs in
therapeutic approaches is a promising but rather unexplored direction in biomedical research. We discovered a
new class of small non-coding RNAs, piwi-interacting RNAs (piRNAs), that…

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Molecular mechanism of the piRNA biogenesis — CALIFORNIA INSTITUTE OF TECHNOLOGY | UNITED STATES | Jun 2011 | Dev Procure