grant
Molecular Mechanism of Human Myogenesis
Organization UNIVERSITY OF GEORGIALocation ATHENS, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY202621+ years oldAddressAdultAdult HumanAffectAllelesAllelomorphsAnimal ModelAnimal Models and Related StudiesAntimorphic mutationAssayBioassayBiochemicalBiological AssayBody TissuesCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCaringCell BodyCell modelCellsCellular modelChromosomal DeletionChromosome DeletionChromosomesCollaborationsComplexDNA TherapyDNA mutationDecreased Muscle ToneDefectDevelopmentDiseaseDisorderDominant NegativeDominant-Negative MutantDominant-Negative MutationE1A Binding Protein p300EP300EP300 geneEmbryoEmbryonicEmbryonic Muscle CellsEventExhibitsFaceFamilyFoundationsFunctional impairmentFundingGene ExpressionGene Transfer ClinicalGenesGeneticGenetic ChangeGenetic InterventionGenetic defectGenetic mutationGenetics-MutagenesisGoalsHeterozygoteHumanHuman ChromosomesHypomyotoniaHypotoniaImpairmentKAT3BLeadLettersLocomotionMapsMediatingModern ManMolecularMolecular TargetMorphologyMuscleMuscle Cell ContractionMuscle CellsMuscle ContractionMuscle DevelopmentMuscle DiseaseMuscle DisordersMuscle HypotonyMuscle TissueMuscle Tone PoorMuscle WeaknessMuscle functionMuscle hypotoniaMuscular ContractionMuscular DevelopmentMuscular DiseasesMuscular HypotoniaMuscular WeaknessMutagenesisMutagenesis Molecular BiologyMutant Strains MiceMutationMyoblastsMyocytesMyopathic ConditionsMyopathic Diseases and SyndromesMyopathic disease or syndromeMyopathyNamesNeonatalOutcomePartial MonosomyPatientsPb elementPerformancePhenotypePhosphoproteinsPrecursor Muscle CellsProcessProliferatingProteinsRNA SeqRNA sequencingRNAseqRationalizationRegulationResearchRoleScienceSeriesStructural ModelsStructureSymptomsSyndromeTestingTissuesToxinTransactivationTransplantationZNFsZinc Finger DomainZinc Finger MotifsZinc FingersZn-finger nucleaseadulthoodassociated symptomclustered regularly interspaced short palindromic repeats screenco-morbid symptomco-occuring symptomcofactorcomorbid symptomconcurrent symptomconferenceconventioncooccuring symptomdevelopmentaldevelopmental diseasedevelopmental disorderdrug developmentexperimentexperimental researchexperimental studyexperimentsfacesfacialgene repair therapygene therapygene-based therapygenetic therapygenome mutationgenomic therapyheavy metal Pbheavy metal leadheterozygosityhistone acetyltransferase p300in vivoinsightinterestmobility aidmobility devicemodel of animalmotor impairmentmouse modelmouse mutantmovement impairmentmovement limitationmurine modelmuscle regenerationmuscularmuscular disordermyogenesisnamenamednamingnovelp300patient advocacy grouppostnatalprotein functionsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssummitsymposiasymposiumsymptom associationsymptom comorbiditytooltrans-activationtranscriptome sequencingtranscriptomic sequencingtransplanttransplant modelzinc finger nucleasezinc finger nucleases
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Description preview
Myoblast fusion is essential for muscle development and regeneration. The long-term goal of our
research is to identify key molecular regulators of this process, focusing on the role of CHAMP1
gene in CHAMP1 syndrome—a severe developmental disorder characterized by muscle
weakness, hypotonia, and motor impairments, often requiring lifelong care.…
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