grant
Molecular genetics and population studies of the KIR and HLA gene complexes
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActivities of Daily LivingActivities of everyday lifeAffectAffinityAlgorithmsAllelesAllelomorphsAntigenic DeterminantsAssayBindingBinding DeterminantsBioassayBiological AssayCD94CalibrationCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell surfaceCell-Free SystemCellfree SystemCellsCellular AssayCellular FunctionCellular PhysiologyCellular ProcessChimera ProteinChimeric ProteinsClinicalComplexCytotoxic cellDataDependenceDevelopmentDiseaseDisease OutcomeDisorderEducationEducational aspectsEffector CellEpidemiological dataEpidemiology dataEpitopesEquilibriumFamilyFusion ProteinGenesGeneticGenetic PolymorphismGenetic studyGenotypeHIVHIV-1HIV-IHIV1HLA-AHLA-A geneHLA-BHLA-B AntigensHLA-CHLA-C AntigensHLAAHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Immune GlobulinsImmune SurveillanceImmunogeneticsImmunoglobulinsImmunologic SurveillanceImmunologyImmunomodulationImmunosurveillanceIndividualInnate Immune ResponseIntervention StrategiesIntracellular Communication and SignalingInvestigationK CellsK lymphocyteKIR3DL1KLRD1KLRD1 geneKP43Killer Cell Lectin-Like Receptor Subfamily D, Member 1 GeneKiller CellsLAV-HTLV-IIILigandsLiteratureLymphadenopathy-Associated VirusManuscriptsMeasurementMeasuresMediatingMessenger RNAMethodsModern ManMolecular GeneticsMolecular InteractionNK Cell ActivationNK CellsNK cell receptor NKB1NKB1 receptorNasopharyngeal CarcinomaNasopharynx CarcinomaNatural Killer Cell ActivationNatural Killer CellsNatureNormal CellPeptide Signal SequencesPeptidesPersonsPlayPopulation StudyProcessPropertyProteinsPublicationsReceptor CellReceptor GeneReceptor ProteinRegulationReporterResolutionRiskRoleScientific PublicationSelf ToleranceSignal PeptideSignal SequencesSignal TransductionSignal Transduction SystemsSignalingStimulusSubcellular ProcessSumSystemT-CellsT-LymphocyteTestingTherapeuticTranscriptUlcerated ColitisUlcerative ColitisVariantVariationVirusVirus-HIVadaptive immune responsebalancebalance functionbiological signal transductioncell assaycell transformationcohortdaily living functiondaily living functionalitydevelopmentaldifferential expressiondifferentially expresseddisease riskdisorder riskepidemiologic dataexperimentexperimental researchexperimental studyexperimentsfunctional abilityfunctional capacitygenetic epidemiologic studygenetic epidemiologyhuman diseaseimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryinsightinterestlentiviral-transducedlentivirally transducedlentivirus transducedlymphoblastoid cell linemRNAmembernovelperipheral bloodpolymorphismpopulation-based studypopulation-level studypreferenceprotein signal sequencereceptorreceptor bindingreceptor boundresolutionsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestudies of populationsstudy of the populationthymus derived lymphocytetooltranscriptional differencestransformed cells
Description preview
Natural killer (NK) cells play a critical role in immune surveillance by recognizing and eliminating virus-infected or transformed cells. Their activity is regulated by a balance between activating and inhibitory signaling from corresponding receptors. In humans, inhibitory NK cell receptors (iNKRs) include members of the highly polymorphic killer…
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