grant
Molecular Determinants of Zinc Regulation of Mammalian Sperm
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 16 Aug 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20253,5 cyclic AMP synthetaseAbscissionAdenyl CyclaseAdenylate CyclaseAdenylyl CyclaseAutoregulationBicarbonatesBiochemistryBiological ChemistryBiologyBody partCannot achieve a pregnancyCatSperCell Communication and SignalingCell SignalingCell membraneComputer AssistedContraceptionContraceptive methodsCytoplasmCytoplasmic MembraneDataDevelopmentDiethyl DicarbonateDiethyl OxydiformateDiethyl PyrocarbonateDiethylpyrocarbonateDifficulty conceivingElectrophysiologyElectrophysiology (science)EndowmentEnzyme GeneEnzymesEthoxyformic AnhydrideEventExcisionExhibitsExtirpationFamilyFamily suidaeFecundabilityFecundityFertilityFertility ControlFertilizationFertilized EggFertilized OvumFluoZin-3FluorescenceFluorometryFoundationsHCO3HomeostasisHumanHuman FigureHuman bodyHydrogen CarbonatesIn VitroIncubatedInfertilityInhibition of FertilizationIntracellular Communication and SignalingKnowledgeLinkMale InfertilityMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMiceMice MammalsMissionModern ManMolecularMotilityMurineMusNICHDNational Institute of Child Health and Human DevelopmentNeurophysiology / ElectrophysiologyPartner in relationshipPatternPenetrationPhysiological HomeostasisPhysiologyPigsPlasma MembranePlayProcessPropertyProteinsProteomicsPublic HealthPublishingPyrocarbonic Acid Diethyl EsterRecombinantsRegulationRemovalResearchRoleRouteSemenSeminalSeminal fluidSignal TransductionSignal Transduction SystemsSignalingSiteSpermSperm MotilitySperm PenetrationSperm-Egg PenetrationSperm-Oocyte PenetrationSperm-Ovum PenetrationSperm-Zona Pellucida PenetrationsSpermatozoaSuidaeSurgical RemovalSwimmingSwineTestingTimeTrace metalZincZn elementZona Pellucidabiological signal transductioncomputer aideddevelopmentaldiethyl ester Dicarbonic acideggelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsextracellularfertility assistancefertility cessationfertility interventionsfertility lossfertility treatmentfertilizationsin vivoinfertileinfertile malesinfertile meninfertility in meninfertility treatmentinnovateinnovationinnovativeinsightmale factor infertilitymatemen facing infertilitymen with infertilitymeternew approachesnovel approachesnovel strategiesnovel strategyplasmalemmaporcinepreventpreventingreproductive successresectionsocial rolesperm analysissperm cellsperm mobilitysperm specific ion channelsuiduptakezoospermzygote
Description preview
Zinc is the most abundant trace metal in the body, and the highest zinc concentrations are found
in semen. Human semen is enriched with 1-3 mM zinc, a 100-fold higher concentration than the
zinc contents of other parts of the body. Moreover, low seminal zinc has been correlated with
male infertility. High concentrations of zinc are also found…
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