grant

Molecular determinants of voltage-gated ion channels' localization and function

Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 6 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026ANK3ANK3 geneAmmon HornAnkyrin 3Ankyrin-GBody TissuesCancersCardiovascular DiseasesCell BodyCell FunctionCell LineCell PhysiologyCell ProcessCell membraneCell modelCell surfaceCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelChronic DiseaseChronic IllnessCornu AmmonisCytoplasmic MembraneDNA Molecular BiologyDevelopmentDiseaseDisorderElectrophysiologyElectrophysiology (science)FutureGlycolipidsGolgiGolgi ApparatusGolgi ComplexHippocampusIon ChannelIon Channel GatingIon Channel GatingsIonic ChannelsK elementKnowledgeLinkMalignant NeoplasmsMalignant TumorMediatingMembrane ChannelsMolecularMolecular BiologyMuscle DiseaseMuscle DisordersMuscular DiseasesMyopathic ConditionsMyopathic Diseases and SyndromesMyopathic disease or syndromeMyopathyNa elementNerve CellsNerve DegenerationNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuron DegenerationNeuronsNeurophysiology / ElectrophysiologyOrganellesPain DisorderPathway interactionsPharmacologyPhosphoproteinsPlasma MembranePotassiumProteinsResearchScaffolding ProteinSodiumStrains Cell LinesSubcellular ProcessTissuesWorkcardiovascular disordercell immortalizationchronic disordercultured cell linedevelopmentalelectrophysiologicalfluorescence imagingfluorescent imaginghippocampalimprovedmalignancymuscular disorderneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneurological diseaseneuronalneuronal degenerationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwayplasmalemmaprogramsrecruitsuperresolution microscopytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttraffickingvoltage
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Project Summary
Voltage-gated ion channels are expressed in multiple tissues and are among the most important drug targets for

treatment of illnesses including chronic pain, muscular, neurological and cardiovascular disorders. Proper

transport and organization of these channels at the plasma membrane is essential for their function. Despite…

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Molecular determinants of voltage-gated ion channels' localization and function — UNIVERSITY OF PENNSYLVANIA | UNITED ST | Dev Procure