grant
Molecular Determinants of the Alveolar Epithelial Plasticity Window
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 15 May 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20250-4 weeks old21+ years oldATAC sequencingATAC-seqATACseqAblationAdultAdult HumanAlveolarAlveolusAssay for Transposase-Accessible Chromatin using sequencingAttenuatedBasal Transcription FactorBasal transcription factor genesBioinformaticsBirthBleoBleomycinBody TissuesBreathingBronchial AlveolusC-EBP Nuclear ProteinC-EBP ProteinsC/EBPCAAT-Enhancer-Binding ProteinsCCAAT Sequence-Specific DNA-Binding ProteinsCCAAT-Enhancer-Binding ProteinsCell BodyCell Communication and SignalingCell DeathCell DifferentiationCell Differentiation processCell MaturationCell SignalingCell secretionCellsCellular SecretionChIP SequencingChIP-seqChIPseqComplexCuesDNA Synthesis FactorDataDefectDevelopmentDistalDown-RegulationEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEndothelial Cell Growth FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpitheliumFGFFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Regulatory FactorFibrosisFibrotic lesions in lungGasesGene Down-RegulationGene ExpressionGene TargetingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionImageInjuryIntracellular Communication and SignalingInvestigationLeannessLineage TracingLungLung Alveolar EpitheliaLung DiseasesLung Respiratory SystemLung SurfactantLung Tissue FibrosisLung scarLung tissue regenerationLung tissue scarMaintenanceMediatingModelingModificationMolecularNatural regenerationNewborn InfantNewbornsParturitionPatientsPerinatalPeripartumPlayPolycombProtein CPulmonary AlveoliPulmonary DiseasesPulmonary DisorderPulmonary FibrosisPulmonary ScarPulmonary SurfactantsPulmonary Tissue fibrosisPulmonary alveolar structureRNA ExpressionRegenerationRegulationReportingRepressionRespiratory AspirationRespiratory InspirationRoleScarring at the lungScarring in the lungSignal TransductionSignal Transduction SystemsSignalingStem Cell likeStretchingSurfaceTestingTherapeuticThinnessTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription RepressionTranscription factor genesTransgenic MiceUpdateWorkadulthoodalveolar epitheliumassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingattenuateattenuatesbiological signal transductioncell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular differentiationcellular lineage mappingcellular lineage trackingchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingdevelopmentaldisease of the lungdisorder of the lungepigeneticallyexperimentexperimental researchexperimental studyexperimentsfibrosis in the lungfibrotic lungfunctional statusgene repressionimagingin vivoinjuriesinjury and repairinnovateinnovationinnovativeinsightinspirationlung alveoluslung developmentlung disorderlung fibrosislung regenerationlung repairlung tissue repairmosaicmouse modelmultiomicsmultiple omicsmurine modelnecrocytosisnew diagnosticsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynewborn childnewborn childrennext generation diagnosticsnext generation therapeuticsnotchnotch proteinnotch receptorsnovelnovel diagnosticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionpanomicsprematureprematurityprogenitorprogenitor capacityprogenitor cell differentiationprogenitor cell likeprogenitor differentiationprogenitor-likeprogramspulmonary regenerationpulmonary repairregeneraterepairrepairedscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial and temporalspatial temporalspatiotemporalstem and progenitor differentiationstem cell characteristicsstem cell differentiationstem-likestemnesssurfactanttranscription factor
Description preview
PROJECT SUMMARY
The alveolus is lined by two epithelial cell types: thin gas-exchanging alveolar type 1 (AT1) cells and cuboidal
surfactant-producing AT2 cells. Both are selected from a common distal progenitor by FGF, Notch, and stretch
signaling. Injury in the adult lung activates AT2 into a facultative progenitor state to regenerate lost AT1…
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