grant
Molecular Determinants of Age-Related Cognitive Decline in the Basal Forebrain to Lateral Entorhinal Cortex Circuit
Organization UNIVERSITY OF GEORGIALocation ATHENS, UNITED STATESPosted 15 Mar 2026Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026AD and related dementiaAD dementiaAD modelAD related dementiaADRDAddressAffectAgeAge associated cognitive deficitAge associated cognitive dysfunctionAge of OnsetAge related memory declineAge related memory deficitAge related memory impairmentAge related pathologiesAge-associated cognitive declineAge-related cognitive declineAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmmon HornAnatomic SitesAnatomic structuresAnatomyAnimalsAttentionBehaviorBehavioral AssayBenign senescent forgetfulnessBrainBrain Nervous SystemBrain regionCareer Transition AwardCell BodyCell NucleusCellsClassificationCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunicationCornu AmmonisCoupledDataData SetDegenerative Neurologic DisordersDeteriorationDisturbance in cognitionDysfunctionEarly InterventionEncephalonEntorhinal AreaEventExpression SignatureFISH TechnicFISH TechniqueFISH analysisFISH assayFluorescence In Situ HybridizationFluorescent in Situ HybridizationFore-BrainForebrainFunctional disorderFutureGene Expression ProfileGeneticGoalsGrantHippocampal FormationHippocampusHumanImpaired cognitionInflammationInvestigatorsKnowledgeLateralLearningMaintenanceMedialMediatorMemoryMemory DeficitMemory impairmentMiceMice MammalsMicroscopyModern ManMolecularMolecular FingerprintingMolecular ProfilingMoodsMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNucleusOutputPerformancePhysiopathologyPopulationPredispositionPrimary Senile Degenerative DementiaProsencephalonRNA SeqRNA sequencingRNAseqResearchResearch PersonnelResearch ResourcesResearchersResourcesSingle-Nucleus SequencingSiteSusceptibilitySystematicsTau forming aggregatesViral VectorVulnerable PopulationsWorkaberrant agingabnormal agingabnormally aggregated tau proteinage associated alterationsage associated changesage associated cognitive impairmentage associated memory declineage associated memory deficitage associated pathologiesage correlated alterationsage correlated changesage dependent alterationsage dependent changesage dependent pathologiesage induced alterationsage induced changesage induced pathologiesage related alterationsage related changesage related cognitive deficitage related cognitive dysfunctionage related cognitive impairmentage related memory dysfunctionage specific alterationsage specific changesage-associated memory impairmentage-induced cognitive declineage-related decline in cognitionage-related decline in cognitive functionagedaged animalaged animalsaged miceaged mouseagesaggregation in tauaging associated alterationsaging associated changesaging associated pathologiesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging dependent pathologiesaging induced alterationsaging induced changesaging induced pathologiesaging pathologiesaging related alterationsaging related changesaging related cognitive declineaging related pathologiesaging specific alterationsaging specific changesalterations with agealzheimer modelanimal old agebasal forebrainbasebasescareercell cortexchanges with agecholinergiccholinergic neuroncognitive changecognitive dysfunctioncognitive functioncognitive losscognitive performancecognitive skilldeclining cognitive functions with agingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdysfunctional age related changedysfunctional agingelderly animalelderly miceentorhinal cortexfilamentous tau inclusiongene expression patterngene expression signaturegene signaturesgenetic signatureglobal gene expressionglobal transcription profilehigh definitionhigh-resolutionhippocampalhistologic studieshistological studieshuman modelimpaired agingjuvenile animalmaladaptive agingmemory dysfunctionmicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentmodel of humanmolecular profilemolecular signaturemouse modelmurine modelnatural agingnerve cell deathnerve cell lossneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuropsychiatric diseaseneuropsychiatric disordernormal agingnormative agingnovelold animalsold micepaired helical filament of taupathological age related changespathological agingpathophysiologypreventpreventingprimary degenerative dementiaprogramsresilienceresilientsNuc-Seqself-aggregate tausenile dementia of the Alzheimer typesingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqspatial memorytau PHFtau accumulationtau aggregatetau aggregationtau fibrillationtau fibrillizationtau filamenttau inclusiontau neurofibrillary tangletau oligomertau paired helical filamenttau polymerizationtau protein accumulationtau protein aggregationtau-tau interactiontranscriptional profiletranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslation strategytranslational approachtranslational strategyvulnerable groupvulnerable individualvulnerable peopleyoung animalτ aggregation
Description preview
PROJECT SUMMARY
The entorhinal cortex (EC) is a critical mediator of cortico-hippocampal communication and thus essential for
memory. Numerous studies identify the EC as the first brain region to display age-related changes such as
accumulation of tau protein as related to Alzheimer’s disease (AD). Structural and functional changes to the EC
have…
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