grant
Molecular Characterization of the SARS-CoV-2 Helicase and High-Throughput Screening to Identify Small Molecule SARS-CoV-2 Helicase Inhibitors as Anti-Viral Medicines
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV vaccineAge related comorbiditiesAnti-viral AgentsAnti-viral TherapyAssayBindingBioassayBiochemicalBiological AssayCOVID crisisCOVID epidemicCOVID pandemicCOVID-19COVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 vaccineCOVID-19 virusCOVID-19 yearsCOVID19 virusCV-19CoV-2CoV2CollectionCombined Modality TherapyCoronaviridaeCoronavirusCoronavirus Infectious Disease 2019DNA HelicasesDNA Unwinding ProteinsDNA unwinding enzymeDevelopmentEC 2.7.7.48ElderlyFutureGS-5734GoalsHigh Throughput AssayImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunochemical ImmunologicImmunologicImmunologic DiseasesImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsInterventionInvestigatorsLife CycleLife Cycle StagesMedicalMedicineMolecularMolecular BankMolecular InteractionMolecular TargetMultimodal TherapyMultimodal TreatmentNon-Polyadenylated RNANucleic AcidsNucleotidesNursing HomesOlder PopulationOrthocoronavirinaePathogenesisPhysical distancingPolymeraseProteinsRNARNA Gene ProductsRNA ReplicaseRNA-Dependent RNA PolymeraseRNA-Directed RNA PolymeraseResearch PersonnelResearch ProposalsResearchersResolutionRibonucleic AcidSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 inhibitorSARS-CoV-2 pandemicSARS-CoV-2 vaccineSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-coronavirus-2 vaccineSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome CoV 2 vaccineSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 inhibitorSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 vaccineSevere acute respiratory syndrome related corona virus 2Social DistanceStructureStructure-Activity RelationshipTherapeuticVekluryViralVirusVirus ReplicationWuhan coronavirusadvanced ageage associated comorbiditiesaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesblock SARS-CoV-2block severe acute respiratory syndrome coronavirus 2chemical librarychemical structure functioncombination therapycombined modality treatmentcombined treatmentcorona viruscoronavirus disease 2019coronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease 2019 vaccinecoronavirus disease 2019 viruscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 vaccinecoronavirus disease-19 viruscoronavirus infectious disease-19death riskdepositorydevelopmentalgeriatrichCoV19helicasehigh riskhigh throughput screeningimmune senescenceimmunosenescenceinfection riskinhibit SARS-CoV-2inhibit severe acute respiratory syndrome coronavirus 2inhibitorlife coursemolecular librarymortality riskmulti-modal therapymulti-modal treatmentnCoV vaccinenCoV-19 vaccinenCoV19 vaccinenCoV2new drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynursing homeolder groupsolder individualsolder personpopulation agingremdesivirrepositoryresolutionssenior citizensevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsmall molecular inhibitorsmall moleculesmall molecule inhibitorsmall molecule librariesstructure function relationshipvaccine against 2019-nCovvaccine against COVID-19vaccine against SARS-CoV-2vaccine against SARS-coronavirus-2vaccine against Severe Acute Respiratory Syndrome CoV 2vaccine against Severe acute respiratory syndrome coronavirus 2vaccine candidates against SARS-CoV-2vaccine for novel coronavirusvaccines preventing COVIDvaccines to prevent COVIDviral infectious disease treatmentviral multiplicationviral replicationvirus multiplication
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The COVID-19 Pandemic caused by the novel Severe Acute Respiratory Syndrome (SARS)- Coronavirus (CoV)-2 has necessitated prompt action by biomedical researchers to study key steps in the virus life cycle and identify viral replication targets for molecular interventions leading to therapeutic options. This project focuses on molecular…
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