grant
Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance
Organization BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Location BOSTON, UNITED STATESPosted 15 Mar 2026Deadline 14 Mar 2028
NIHUS FederalResearch GrantFY20262-photonAD dementiaAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimalsAreaBRAIN initiativeBehaviorBehavioralBiologicalBrainBrain Nervous SystemBrain Research through Advancing Innovative Neurotechnologies initiativeBrain regionCalciumCell BodyCellsCommunicationDiseaseDisorderDissectionEncephalonEnvironmentEventExpression SignatureFoundationsGene ExpressionGene Expression ProfileGenesImageImmediate MemoryInformation StorageIon ChannelIonic ChannelsLinkMaintenanceMapsMeasurementMeasuresMembraneMembrane ChannelsMental HealthMental HygieneMiceMice MammalsModelingMolecularMonitorMurineMusNational Institutes of HealthNerve CellsNerve UnitNervous SystemNeural CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNoisePopulationPopulation DynamicsPositionPositioning AttributePrimary Senile Degenerative DementiaProcessPropertyPsychological HealthRecurrenceRecurrentResistanceResolutionRetrievalSchizophreniaSchizophrenic DisordersSensoryShort-Term MemorySignaling MoleculeSpecificityStimulusSynapsesSynapticTestingThalamic structureThalamusTracerUnited States National Institutes of HealthWorkanatomical tracingbiologiccell typecognitive functioncognitive processdementia praecoxexperiencefrontal cortexfrontal lobegene expression patterngene expression signatureimaginginsightmembrane structuremental functionneuralneural circuitneural circuitryneural networkneurocircuitryneuronalneuropsychiatric diseaseneuropsychiatric disorderoptogeneticsprimary degenerative dementiaresistantresolutionsschizophrenicsegregationsenile dementia of the Alzheimer typesensory cortexspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssynapsesynaptic circuitsynaptic circuitrythalamictheoriestooltranscriptional profiletranscriptional signaturetwo-photonworking memory
Description preview
PROJECT SUMMARY
Working memory allows past events to be transiently maintained in the brain so that it can be compared with
ongoing experiences to drive behavior. This cognitive process has been shown to be severely impacted by the
progression of many neuropsychiatric diseases and disorders. Thus, it is critical to understand the components
of…
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