grant
Molecular cartography of initiating and infiltrating glioma cells using multisector sampling and spatial transcriptomics
Organization TRANSLATIONAL GENOMICS RESEARCH INSTLocation PHOENIX, UNITED STATESPosted 15 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20263-D Images3-D image3D image3D images4-dimensionalAcademic Medical CentersAddressArchitectureAreaAstrocytesAstrocytic GliomaAstrocytic NeoplasmAstrocytic TumorAstrocytomaAstrocytusAstrogliaAstrogliomaAutopsyAxonBehavioralBlood VesselsBrainBrain CancerBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain StemBrain TumorsBrain regionBrainstemCAR T cell therapyCAR T therapyCNS Nervous SystemCancer PatientCancersCell BodyCellsCentral Nervous SystemCharacteristicsCitiesClinical ProtocolsDNA MethylationDNA methylation profilingDNA seqDNA sequencingDNAseqDataDetectable Residual DiseaseDevelopmentDiffuseDiffuse PatternDiffusionDissectionEncephalonEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvaluationEvolutionFour-dimensionalFutureGene ExpressionGenomicsGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaImageImmuneImmune mediated therapyImmunesImmunologically Directed TherapyImmunotherapyIndividualInfiltrationInvadedLocal TherapyLocalized TherapyLocationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignantMalignant - descriptorMalignant CellMalignant Glial NeoplasmMalignant Glial TumorMalignant GliomaMalignant NeoplasmsMalignant Neuroglial NeoplasmMalignant Neuroglial TumorMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMapsMath ModelsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethyl-SeqMethylSeqMethylation sequencingMinimal Residual DiseaseModelingMolecularNMR ImagingNMR TomographyNPCNeoplastic Colony-Forming UnitsNeoplastic Stem CellsNerve CellsNerve UnitNeural CellNeural Stem CellNeuraxisNeurocyteNeuroglial NeoplasmNeuroglial TumorNeuronsNuclear Magnetic Resonance ImagingNuclear Pore ComplexOutcome StudyPatientsPhenotypePhylogenetic AnalysisPhylogeneticsPopulationProgenitor CellsPrognosisRNA SeqRNA sequencingRNAseqRecurrenceRecurrentResidual NeoplasmResidual TumorsReverse engineeringRouteSamplingScanningSiteStem Cell likeTestingThree-Dimensional ImageTimeTissue SampleTreesTumor CellTumor Cell InvasionTumor ExpansionTumor InvasionTumor Stem CellsTumor TissueUniversity Medical CentersVentricularZeugmatographyastrocytic gliacancer cellcancer microenvironmentcancer typecell typechimeric antigen receptor (CAR) T cell therapychimeric antigen receptor T cell therapychimeric antigen receptor T therapydevelopmentaldiffuseddiffusesdiffusingdiffusionsdriver lesiondriver mutationeffective therapyeffective treatmententire genomeepigeneticallyfull genomegenome sequencingglial-derived tumorglioblastoma multiformehigh definitionhigh-resolutionimagingimaging studyimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapymalignancymathematic modelmathematical modelmathematical modelingmultidisciplinarymutantnecropsyneoplasm/cancerneoplastic cellnerve stem cellneuralneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuroglia neoplasmneuroglia tumorneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitorneurosurgeryoligodendrocyte precursoroligodendrocyte precursor celloligodendrocyte progenitoroligodendrocyte stem celloligodendrogliomaoptimal therapiesoptimal treatmentspatient prognosispostmortemprecursor cellprogenitor and neural stem cellsprogenitor capacityprogenitor cell likeprogenitor-likeprognosticationreconstructionresidual diseasespatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial temporalspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporalspongioblastoma multiformestem cell characteristicsstem cellsstem-likestemnesssubstantia albatargeted sequencingtherapy optimizationtranscriptome sequencingtranscriptomic sequencingtranscriptomicstreatment optimizationtreatment planningtumortumor initiationtumor microenvironmenttumor progenitortumorigenictumors in the brainvascularwhite matterwhole genome
Description preview
SUMMARY
Diffuse dissemination of tumor cells into the brain is one of the key problems impacting optimal treatment of
gliomas. We hypothesize that distinct types of tumor cells harbor characteristic diffusion patterns. Specifically,
we suspect that NPC-like cells predominate in the cortical layers and interact with the laminar extension of…
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