grant
Molecular Basis of Obesity and Obesity-induced Metabolic Diseases
Organization NATIONAL HEART, LUNG, AND BLOOD INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025Amino AcidsAutoregulationBindingBiologicalCREBCREB1CREB1 geneConserved SequenceD-GlucoseDextroseElementsFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2Functional RNAGene TranscriptionGenetic TranscriptionGlucoseHepaticHomeostasisHumanInvestigationLipidsLiverMechanistic Target of RapamycinMetabolicMetabolic DiseasesMetabolic DisorderMiceMice MammalsModern ManMolecularMolecular InteractionMurineMusNon-Polyadenylated RNANoncoding RNANontranslated RNANutrientObese MiceObesityPathway interactionsPhysiologicPhysiologicalPhysiological HomeostasisRAFT1RNARNA ExpressionRNA Gene ProductsRNA based therapeuticsRNA based therapyRNA therapyRibonucleic AcidRoleTherapeuticThesaurismosisTranscriptionTriglyceride MetabolismUntranslated RNAadiposityaminoacidbiologiccAMP Response Element-Binding Protein 1corpulencehepatic body systemhepatic organ systemin vivomTORmammalian target of rapamycinmetabolism disordernoncodingob/ob mousepathwayprogramssocial roletherapeutic RNAtherapeutic targettranslational opportunitiestranslational potential
Description preview
Using a sequence-independent approach, we systematically identified pairs of conserved lncRNA metabolic regulators (fcLMRs) between humans and mice. Among them, h/mLMR1 was shown to regulate hepatic triglyceride metabolism through a nutrient-sensitive amino acid–mTOR–SREBP1 pathway. This finding established a paradigm for dissecting the…
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