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Molecular Basis of Mammalian Manganese Homeostasis

Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 21 Sept 2016Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025AffectAlimentary CanalAnemiaAntisense AgentAntisense OligonucleotidesApicalAttenuatedAutoregulationBileBile JuiceBile fluidBiliaryBiologyBloodBlood Reticuloendothelial SystemCopperCu elementDNA mutationDataDefectDevelopmentDietDietary IronDigestive TractDisclosureDiseaseDisorderDysfunctionECSFEndocrine Gland SecretionEnterocytesEpoetinErythrocyte CountErythrocyte MeasurementErythrocyte NumberErythropoiesisErythropoietinExcretory functionExtrahepaticFe absorptionFe deficiencyFe elementFunctional disorderFundingGI TractGastrointestinal TractGastrointestinal tract structureGenesGeneticGenetic ChangeGenetic defectGenetic mutationGoalsHealthHematologyHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatobiliaryHepatocyteHepc peptideHereditaryHereditary DiseaseHomeostasisHormonesHumanHypoxiaHypoxicImpairmentInborn Genetic DiseasesInformation DisclosureInheritedInherited disorderIntestinalIntestinesInvestmentsIronKO miceKnock-out MiceKnockout MiceLinkLiverLiver CellsLiver diseasesMaintenanceManganeseMetabolicMetalsMiceMice MammalsMicroscopicMn elementModelingModern ManMolecularMurineMusMutant Strains MiceMutationNervous System DiseasesNervous System DisorderNeurologicNeurologic DisordersNeurologicalNeurological DisordersNull MouseNutrientOrganOxygen DeficiencyPathologyPathway interactionsPatientsPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlayPolycythemiaProtein ExportProtein Export PathwayRadioactive IsotopesRadioisotopesRadionuclidesRed Blood Cell CountReportingResearchRiskRoleSmall IntestinesTechniquesTestingTherapeuticTherapeutic HormoneToxic effectToxicitiesabsorptionalimentary tractantisense oligoattenuateattenuatesboweldesigndesigningdevelopmentaldietarydietary Fedietsdigestive canalerythrocyte colony stimulating factorerythroid developmentexcretionferroportinferroportin1 proteingenome mutationhematopoietinhepatic body systemhepatic diseasehepatic organ systemhepatopathyhepcidinhereditary disorderheritable disorderin vivoinborn errorinherited diseasesinherited genetic diseaseinherited genetic disorderinhibitoriron absorptioniron deficiencyliver disordermetal transporting protein 1mouse mutantneurological diseasenovelpathophysiologypathwaypharmacologicsmall bowelsocial rolesolute carrier family 40 (iron-regulated transporter), member 1stem

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Metals are essential for human health yet potentially toxic in excess. Our understanding of metal homeostasis stems prominently from studies of inherited diseases of metal deficiency and excess. The molecular basis of manganese (Mn) homeostasis is poorly understood relative to other metals, given that inherited Mn-related diseases were only…

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Molecular Basis of Mammalian Manganese Homeostasis β€” BROWN UNIVERSITY | UNITED STATES | Sept 2016 | Dev Procure