grant
Molecular basis for functional S1PR1 antagonists in the treatment of comorbid migraine and temporomandibular disorders
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20252,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamateAgonistAnimal ModelAnimal Models and Related StudiesAstrocytesAstrocytusAstrogliaAttenuatedBehavioralBiochemicalBiochemistryBiological ChemistryBlood SerumCell Communication and SignalingCell SignalingChronicCoupledDataDevelopmentDiseaseDisorderDoseEdg ReceptorsElectrophysiologyElectrophysiology (science)Evidence based treatmentFDA approvedFamilyFemaleGene ExpressionGeneticGliaGlial CellsIL-1IL1ImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInflammasomeInflammationInflammatoryInterleukin IInterleukin-1InterventionIntracellular Communication and SignalingInvestigationKnowledgeKolliker's reticulumLaboratoriesLigandsLinkLymphocyte-Stimulating HormoneMEFV gene productMS treatmentMacrophage Cell FactorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMigraineMigraine HeadacheModelingMolecularNerve CellsNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronsNeurophysiology / ElectrophysiologyNociceptionNon-neuronal cellNonneuronal cellNucleus of the Fifth NerveOutcomePainPain DisorderPainfulPathway interactionsPatientsPerformancePharmacologic ActionsPharmacologyPilot ProjectsPopulationPositionPositioning AttributePre-Clinical ModelPreclinical ModelsPrevalencePreventiveProcessProductionProteomicsProtocolProtocols documentationPublic HealthPublishingReceptor ProteinReportingRiskRodentRodentiaRodents MammalsRoleS1P ReceptorSafetySerumSeveritiesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSphingosine-1-Phosphate ReceptorSpinalSymptomsT Helper FactorTMD painTMD treatmentTMJ DiseasesTMJ DisordersTMJDTemporomandibular DisordersTemporomandibular Joint DiseasesTemporomandibular Joint DisordersTemporomandibular Joint and Muscle DisorderTemporomandibular disorder painTemporomandibular joint disease painTemporomandibular joint disorder painTestingTherapeuticTherapeutic InterventionTimeTranslatingTreatment outcomeTrigeminal NucleiTrigeminal PainTrigeminal SystemValidationWorkantagonismantagonistastrocytic gliaattenuateattenuatesbiological signal transductionclinical translationclinically translatableco-morbidco-morbiditycomorbiditydevelopmentaldisabilitydisease modeldisorder modelelectrophysiologicalexperiencefield based datafield learningfield studyfield testgenetic approachgenetic strategyin vivoinsightinterdisciplinary approachintervention therapylymphocyte activating factormalemarenostrinmodel of animalmolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentmultidisciplinary approachmultiple sclerosis therapymultiple sclerosis treatmentnerve cementneural inflammationneurobiological mechanismneuroinflammationneuroinflammatoryneuronalneuropathic painnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnociceptivenon-narcotic analgesicnon-opiate analgesicnon-opioidnon-opioid analgesicnon-opioid therapeuticsnonnarcotic analgesicsnonopiate analgesicnonopioidnonopioid analgesicsnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpain modelpain outcomepain-related outcomepainful neuropathypathwaypatient populationpharmacologicpilot studypre-clinicalpre-clinical developmentpreclinicalpreclinical developmentpreventpreventingpyrinreceptorresponsesocial rolesphingosine 1-phosphatetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttemporomandibular disorder treatmenttherapeutic outcometherapeutic targettherapy outcometopiramatetreatment strategytrigeminalvalidations♀♂
Description preview
Project Summary/Abstract
Overlapping pain conditions greatly exacerbate patients’ pain experience. This includes comorbid migraine and
temporomandibular disorders (TMDs), which is associated with a reciprocal increase in their prevalence/severity,
increased risk of chronification, negatively impacting therapeutic outcomes. This underscores this…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click