grant
Molecular and Clinical Studies of Insulin Resistance
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AcromegalyAdipose tissueAdult-Onset Diabetes MellitusAutoantibodiesBerardinelli syndromeBerardinelli-Seip Congenital LipodystrophyBerardinelli-Seip-Lawrence syndromeBlood PlasmaBody TissuesBone DiseasesCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCausalityCell BodyCellsClinical ResearchClinical StudyCollaborationsD-GlucoseDNA mutationDextroseDiabetes MellitusDiseaseDisorderDunnigan Familial Partial Lipodystrophy Dunnigan SyndromeDunnigan SyndromeDysfunctionDyslipidemiasEndocrine Gland SecretionEtiologyFDA approvedFamilial generalized lipodystrophyFamilial partial lipodystrophyFatty TissueFunctional disorderGeneralized Lipoatrophic Diabetes MellitusGenesGenetic ChangeGenetic defectGenetic mutationGlucoseHIV Lipodystrophy SyndromeHIV-Associated LipodystrophyHIV-Associated Lipodystrophy SyndromeHeart VascularHepatic DisorderHistoryHormonesHumulin RInappropriate GH Secretion Syndrome (Acromegaly)Inappropriate Growth Hormone Secretion Syndrome (Acromegaly)InsulinInsulin ReceptorInsulin Receptor Protein-Tyrosine KinaseInsulin ResistanceInsulin Signaling PathwayInsulin-Dependent Tyrosine Protein KinaseIntramural ProgramIntramural Research ProgramKetosis-Resistant Diabetes MellitusKidney DiseasesKoberling-Dunnigan SyndromeLawrence syndromeLearningLipodystrophyLipodystrophy SyndromeLiver diseasesMaturity-Onset Diabetes MellitusMetabolicMiescher syndrome 2MolecularMolecular GeneticsMutationNAFLDNIDDKNIDDMNational Institute of Diabetes and Digestive and Kidney DiseasesNatural HistoryNephropathyNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityOrganOrphan DiseasePathway interactionsPatientsPhysiologyPhysiopathologyPlasmaPlasma SerumRare DiseasesRare DisorderReceptor GeneRecording of previous eventsRegular InsulinRenal DiseaseReportingResistanceReticuloendothelial System, Serum, PlasmaSeip syndromeSlow-Onset Diabetes MellitusSomatotropin Hypersecretion Syndrome (Acromegaly)Stable Diabetes MellitusSyndromeT2 DMT2DT2DMTexasTherapeuticTherapeutic HormoneTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUniversitiesacromegalic featuresadiposeadiposityadult onset diabetesautoimmune antibodyautoreactive antibodybone disordercardiovascular disordercausationcirculatory systemcongenital lipoatrophic diabetescongenital lipodystrophycorpulencediabetesdisease causationgeneralized lipodystrophygenome mutationhepatic diseasehepatopathyhistoriesinsulin resistantinsulin toleranceinterestketosis resistant diabeteskidney disorderlipodystrophy-acromegaloid gigantism syndromeliver disordermaturity onset diabetesnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseaseorphan disorderpathophysiologypathwaypatient populationrenal disorderreproductivereproductive functionresistantresponseself reactive antibodytype 2 DMtype II DMtype two diabeteswhite adipose tissueyellow adipose tissue
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Description preview
We have had a long-standing interest in the etiology of severe insulin resistance. Initially, we identified mutations in the insulin receptor gene and studied a group of patients with autoantibodies against the insulin receptor. More recently, we have concentrated on lipodystrophy syndromes: a group of heterogeneous syndromes characterized by…
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