grant
Molecular and Circuit Analyses of Color Discrimination without Opsins
NIHUS FederalResearch GrantFY2025AddressAdoptedAmberAnimal BehaviorAnimalsBehaviorBehavioralBiologic ModelsBiologicalBiological ModelsBlindnessC elegansC. elegansC.elegansCaenorhabditis elegansCalciumCircadian DysregulationCognitive DiscriminationColorCommunicationComplexCuesDiscriminationDysfunctionEnvironmentExposure toEyeEyeballFacultyFamilyFellowshipFoodFoundationsFunctional disorderGeneticGenetic TechnicsGenetic TechniquesGoalsGurHealthHealth behaviorHumanImageInsectaInsectsInsects InvertebratesIon ChannelIonic ChannelsKnowledgeLaboratoriesLifeLightMeasuresMechanical StimulationMechanoreceptorsMediatingMembrane ChannelsMethodsModel SystemModern ManMolecularMolecular GeneticsNematodaNematodesNerve CellsNerve UnitNervous SystemNeural CellNeurobiologyNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsOpsinOutcomePathway interactionsPatternPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiopathologyPositionPositioning AttributeProcessReceptor ProteinResearchResolutionRod-OpsinSensoryShapesSiteSleep disturbancesSourceSynapsesSynapticSystemSystems IntegrationTechnical ExpertiseTestingTrainingTransducersTreesVisible LightVisible Light RadiationVisible RadiationVisualVisual ReceptorWorkaberrant sleepbehavior responsebehavioral responsebiologiccircadian abnormalitycircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentdisrupted sleepdisturbed sleepexperimentexperimental researchexperimental studyexperimentsfeedinghealth related behaviorimagingimpaired sleepimprovedinsightintegrated systeminterestirregular sleepkinematic modelkinematicslight effectslight intensitymemberneural circuitneural circuitryneural imagingneural mechanismneural networkneuro-imagingneurobiologicalneurobiological mechanismneurocircuitryneuroimagingneurological imagingneuromechanismneuronalnoveloptogeneticspathophysiologypathwayperceptual stimulusphysicochemical phenomena related to the sensesprogramsreceptorresolutionsresponseroundwormsensory integrationsensory stimulussleep controlsleep disruptionsleep dysregulationsleep regulationsleep/wake disruptionsleep/wake disturbancesleep/wake regulationsynapsesynaptic circuitsynaptic circuitrysystem architecturesystem integrationtechnical skillstoolultra violetultravioletvision lossvisual loss
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PROJECT SUMMARY
Light is a critical environmental cue that shapes daily health behaviors such as navigation, foraging, and sleep
regulation across the animal kingdom. In humans, disruptions in light-sensing pathways can result in blindness,
circadian dysfunction, and other health issues. Studying neurobiological mechanisms underlying light-sensing…
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