grant
Molecular and Cellular Pathogenesis of Pulmonary Langerhans Cell Histiocytosis
Organization UNIVERSITY OF CINCINNATILocation CINCINNATI, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2027
NIHUS FederalResearch GrantFY2026AddressAdoptive TransferAssayAutoregulationB-raf-1BRAFBRAF geneBenignBioassayBiologicalBiological AssayBiopsyBlocking AntibodiesBlood leukocyteBlood monocyteCCL20CCL20 geneCCL7CCL7 geneCD11cCell AgingCell BodyCell MaturationCell SenescenceCell TherapyCell surfaceCellsCellular AgingCellular Immune FunctionCellular SenescenceChemokine, CC Motif, Ligand 20Chemotactic CytokinesChronicCigarette SmokerClinical TrialsCommunitiesCystCystic LesionCytolysisDNA mutationDataDendritic CellsDevelopmentDiagnosisDiseaseDisorderEosinophilic GranulomaEosinophilic Xanthomatous GranulomaEventExhibitsExodus 1Exposure toGeneralized HistiocytosisGenerationsGenetic ChangeGenetic defectGenetic mutationGoalsHistiocytosis XHomeostasisHomologous Chemotactic CytokinesHumanITGAXITGAX geneImmune EvasionIn VitroInduced DNA AlterationInduced MutationInduced Sequence AlterationInflammationInflammatoryIntercrinesInterstitial Lung DiseasesKinasesKnowledgeLAK CellsLARCLangerhans-Cell GranulomatosisLangerhans-Cell HistiocytosisLesionLetterer-Siwe DiseaseLeukocytesLeukocytes Reticuloendothelial SystemLifeLigandsLinkLungLung DiseasesLung Respiratory SystemLymphatic cellLymphocyteLymphocyticLymphokine-Activated Killer CellsLysisLytotoxicityMAPK Signaling PathwayMAPK Signaling Pathway PathwayMARCMCP-3MCP3MIP3AMacrophage Inflammatory Protein 3-AlphaMarrow leukocyteMarrow monocyteMediatingMiceMice MammalsModelingModern ManMolecularMolecular TargetMorbidityMurineMusMutant Strains MiceMutationMyelogenousMyeloidNC28NatureNeoplasmsNodulePathogenesisPathologyPathway interactionsPatientsPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPre-Clinical ModelPreclinical ModelsProcessProductionPublic HealthPulmonary DiseasesPulmonary DisorderRAFB1Receptor ProteinReplicative SenescenceReportingResearchRoleSCYA20SCYA7SIS cytokinesSmall Inducible Cytokine Subfamily A, Member 20SourceSpecificityTestingTimeTransphosphorylasesUpregulationVeiled CellsWhite Blood CellsWhite Cellbiologiccell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapychemoattractant cytokinechemokinecigarette smoke exposurecytokinecytotoxiccytotoxicitydevelop therapydevelopmentaldisease of the lungdisorder of the lungeffective therapyeffective treatmentevidence baseexperimentexperimental researchexperimental studyexperimentsexposure to cigarette smokegenome mutationhistiocyteimmune evasiveimmune functioninsightintervention developmentlangerinlung disorderlung lesionlymph cellmonocytemortalitymouse mutantmutantneoplasianeoplastic growthnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypre-clinical studypreclinical studypreservationpulmonarypulmonary lesionreceptorrecruitreplicative agingsocial roletherapeutic targettherapy developmenttreatment developmentv-raf Murine Sarcoma Viral Oncogene Homolog B1white blood cellwhite blood corpuscle
Description preview
Project Summary. Pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare interstitial lung disease,
which occurs almost exclusively in cigarette smokers and has a median duration of survival from of of
12.5 years. PLCH is characterized by,Langerin+ dendritic cell (DC) accumulation, inflammatory lesions,
nodule formation and cystic remodeling.…
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