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Molecular and biophysical mechanism of plasma membrane internalization during nonclathrin endocytosis
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Sept 2019Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DActin FilamentsActinsApicalBindingBiologic ModelsBiological ModelsBiophysical ProcessBiophysicsBlebBlisterBlood Plasma CellBullaBullous LesionCalibrationCell BodyCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell PolarityCell ProcessCell membraneCellsCellular FunctionCellular MatrixCellular MembraneCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCharacteristicsChimera ProteinChimeric ProteinsClassificationClassification SchemeClathrinCollaborationsComplexComputer ModelsComputerized ModelsCytoplasmic MembraneCytoskeletal SystemCytoskeletonDevelopment PolarityDiploidDiploidyDisseminated Malignant NeoplasmEndocytosisEventExtracellular FluidFeedbackFluorescenceFluorescence Light MicroscopyFluorescence MicroscopyFoundationsFusion ProteinGatekeepingGenerationsImageLeadLightMachine LearningMalignant CellMath ModelsMeasuresMechanicsMembraneMetabolic GlycosylationMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMicrofilamentsMicroscopyModel SystemModelingMolecularMolecular InteractionMonitorMyofilamentsNeoplasm MetastasisOsmosisPb elementPeptide DomainPhotoradiationPhysiologicPhysiologicalPlasma CellsPlasma MembranePlasmacytesPolymersPostdocPostdoctoral FellowProcessProgenitor CellsProtein DomainsProteinsReceptor ProteinResearchResearch AssociateRoleSecondary NeoplasmSecondary TumorSiteStressSubcellular ProcessSurfaceSystematicsTertiary Protein StructureTestingTrainingVesicationWorkanalytical toolbasebasesbiophysical foundationbiophysical mechanismbiophysical principlesbiophysical sciencescancer cellcancer metastasiscell imagingcell motilitycellular imagingcellular polaritycomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingepithelial to mesenchymal transitionexperimentexperimental researchexperimental studyexperimentsextracellularfluorescence imagingfluorescent imaginggatekeeperglycosylationheavy metal Pbheavy metal leadhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsimaginginduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibitorinterestintracellular skeletonlab assignmentlab experimentlaboratory activitylaboratory assignmentlaboratory exerciselaboratory experimentlive cell imagelive cell imaginglive cellular imagelive cellular imagingmachine based learningmachine learning based methodmachine learning methodmachine learning methodologiesmathematic modelmathematical modelmathematical modelingmechanicmechanicalmembrane structuremodel-based simulationmodels and simulationmulti-scale computational modelingmulti-scale mathematical modelingmulti-scale modelingmultiscale computational modelingmultiscale mathematical modelingmultiscale modelingnovelphysical modelplasmalemmaplasmocytepolarized cellpolymerpolymericpolymerizationpost-docpost-doctoralpost-doctoral traineepost-doctoral trainingpredictive modelingprotein biomarkersprotein functionprotein markersreceptorreceptor internalizationrecruitresearch associatessimulationskillssocial rolespatial and temporalspatial temporalspatiotemporalstem cellstemporal measurementtemporal resolutiontheoriesthree dimensionaltime measurementtumor cell metastasis
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Description preview
During endocytosis, the cell's plasma membrane is deformed and internalized to bring in extracellular
cargo and transmembrane receptors. Nonclathrin/noncaveolar (CLIC/GEEC) endocytosis internalizes
glycosylated receptors and extracellular fluid, and is connected to cell polarity development, blebbing, and the
epithelial-to-mesenchymal transition…
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