grant
Modulation of the tumor microenvironment by Fusobacterium nucleatum and co-infecting microbes in colorectal cancer
Organization UNIVERSITY OF TX MD ANDERSON CAN CTRLocation HOUSTON, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AdhesionsAffectAntibiotic TherapyAntibiotic TreatmentAutomobile DrivingB fragilisB intermediusB. fragilisB. intermediusBacteriaBacteroides fragilisBacteroides intermediusBody TissuesBuccal CavityBuccal Cavity Head and NeckC fusiformeC. fusiformeCD152CD152 AntigenCD152 GeneCTLA 4CTLA-4 GeneCTLA4CTLA4 geneCTLA4-TMCancer ModelCancer PatientCancer TreatmentCancerModelCancersCarcinomaCavitas OrisCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell modelCell-to-Cell InteractionCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular modelClinicalCollectionColon CancerColon CarcinomaColorectal CancerCommunity ActionsCorynebacterium fusiformeCytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Cytotoxic T-Lymphocyte-Associated Protein 4Cytotoxic T-Lymphocyte-Associated Serine Esterase-4DiseaseDisease ProgressionDisorderDistantDistant CancerDistant MetastasisEffectivenessEpithelial CellsEpithelial cancerExhibitsF fusiformisF nucleatumF nucleatusF. fusiformisF. nucleatumF. nucleatusFusiformis fusiformisFusiformis nucleatusFusobacterium nucleatumGene TranscriptionGenetic TranscriptionHumanImmuneImmunesImmunityIndividualInfectionInfiltrationIntracellular Communication and SignalingInvadedKnowledgeLower GI TractLower Gastrointestinal TractMalignant CellMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMicrobeMicrobiomicsModelingModern ManMolecularMolecular AnalysisMouthMurineMusMyeloid CellsNatureNeoplasm MetastasisOral Cavity Squamous Cell CarcinomaOral cavityOral squamous cell carcinomaOutcomeP intermediaP. intermediaPD 1PD-1PD1PDX modelPatient derived xenograftPatientsPhysiologicPhysiologicalPredispositionPrevotella intermediaProliferation MarkerProteinsRNA ExpressionRecurrent diseaseRelapseRelapsed DiseaseResearchRoleSecondary NeoplasmSecondary TumorShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSpatial DistributionSubcellular ProcessSusceptibilityT cell infiltrationTechniquesTestingTherapeutic InterventionTissuesTranscriptionTumor TissueUpregulationWorkanti-cancer therapybacterial communitybacterial disease treatmentbacterial infectious disease treatmentbiological signal transductioncancer cellcancer in the coloncancer metastasiscancer microenvironmentcancer preventioncancer progressioncancer therapycancer typecancer-directed therapycell behaviorcell motilitycell typecellular behaviorco-infectioncohortcoinfectioncolon cancer patientscolorectal cancer metastasiscolorectal cancer patientscolorectal cancer progressioncolorectal cancer therapycolorectal cancer treatmentcommunity microbescytotoxic T-lymphocyte antigen 4drivingepidemiology research studyepidemiology studyepidemiology surveyepithelial carcinomaexperiencehost microbe associationhost microbe relationshiphost microbiotahost microflorahost-microbe interactionshost-microbial interactionshost-microorganism interactionsimmune check pointimmune checkpointimmune microenvironmentimmunecheckpointimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentin vitro Modelinnovateinnovationinnovativeinsightintervention therapymalignancymembermetastatic colo-rectalmetastatic colo-rectal cancermetastatic colo-rectal carcinomametastatic colon cancermetastatic colorectalmetastatic colorectal cancermetastatic colorectal carcinomamicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobial hostmicrobiome researchmicrobiome sciencemicrobiome studiesmicrobiotamicrofloramicroorganism communitymouth SCCmouth squamous cell carcinomamultiomicsmultiple omicsmultispecies consortianeoplasm progressionneoplasm/cancerneoplastic progressionnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetoral cavity SCCoral microbial communityoral microbiotaoral microfloraoral squamous canceroral squamous carcinomapanomicspatient derived xenograft modelpatient prognosispolymicrobial communityprogrammed cell death 1programmed cell death protein 1programmed death 1programsrecruitresident microbesresident microfloraresponse to therapyresponse to treatmentscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2social rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial multiomicsspatial omicsspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatial tri-omicsspatially resolved transcriptomicsspatio transcriptomicssystemic lupus erythematosus susceptibility 2therapeutic responsetherapy responsetranslation strategytranslational approachtranslational impacttranslational strategytreatment responsetreatment responsivenesstumortumor cell metastasistumor growthtumor immune microenvironmenttumor microenvironmenttumor progressiontumor-immune system interactions
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PROJECT SUMMARY/ABSTRACT
Fusobacterium nucleatum (Fn), a bacterium typically found in the human oral cavity and a rare member of the
lower gastrointestinal tract microbiota in healthy individuals, is significantly enriched in human colorectal cancer
(CRC) tissues. Extensive epidemiological studies have established a strong association between high…
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