grant
Modulation of Corneal Endothelial Mitochondrial Activity and Dysfunction by Estrogen
Organization TRUSTEES OF INDIANA UNIVERSITYLocation BLOOMINGTON, UNITED STATESPosted 30 Sept 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AccelerationActinic RaysActive OxygenAcuteAffectAgeAge related macular degenerationAge-Related MaculopathyAgonistAntioxidantsApoptosisApoptosis PathwayBasement membraneBody TissuesCarcinogen-DNA AdductsCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCataractCell DensityCellular MorphologyCorneaCorneal EndotheliumCorneal edemaCultured CellsDNADNA AdductsDNA mutationDeoxyribonucleic AcidDepositDepositionDevelopmentDry Eye SyndromesDry eye diseaseDysfunctionEndothelial CellsEndotheliumEstrogen ReceptorsEstrogen Replacement TherapyEstrogen declineEstrogenic AgentsEstrogenic CompoundsEstrogensEye DropsEye diseasesEyedropsFemaleFuchs endothelial corneal dystrophyFuchs' Endothelial DystrophyFuchs' dystrophyFunctional disorderGene ExpressionGenesGeneticGenetic ChangeGenetic defectGenetic mutationGlaucomaGoalsGonadal Steroid HormonesHealthHeart VascularIPO-BIncidenceIndophenol Oxidase BIntervening SequencesIntronsKO miceKeratoconjunctivitis SiccaKnock-outKnock-out MiceKnockoutKnockout MiceLacrimal deficiencyLifeLipidsMNSODMacular degenerationMacular degenerative diseaseManganese Superoxide DismutaseMeasuresMenopauseMetabolicMethodsMiceMice MammalsMitochondriaMitochondrial Superoxide DismutaseMn Superoxide DismutaseMn-SODModelingMorphologyMurineMusMutant Strains MiceMutationNuclearNull MouseOcular desiccationOsteoporosisOxidative StressOxygen ConsumptionOxygen RadicalsPathway interactionsPatientsPhenotypePhysiologyPhysiopathologyPopulationPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePre-MenopausePre-menopausal PeriodPremenopausalPremenopausal PeriodPremenopausePrevalencePro-OxidantsProgrammed Cell DeathProteinsReactive Oxygen SpeciesResearch SpecimenRetinal Ganglion CellsRodent ModelSOD2SOD2 geneSeveritiesSex HormonesSex Steroid HormonesSpecimenSuperoxide Dismutase 2T cell factor 4T cell transcription factor 4T-Cell-Specific Transcription Factor 4TCF-4TCF4TCF7L2TCF7L2 geneTcf4 transcription factorTcf712 transcription factorTestingTherapeutic EstrogenThickThicknessTimeTissuesTranscription Factor 7-Like 2Transgenic OrganismsUV lightUV radiationUV raysUltraviolet RaysVasodilatationVasodilationVasorelaxationWomanafter menopauseage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophyagesbiological sexbonecardiovascular disordercataractogenesiscataractous lensescell morphologycirculatory systemcornea edemacornealcorneal endothelialdecline in estrogendecrease estrogendecrease in estrogendensitydevelopmentaldry eyedystrophia epithelialis corneaeendothelial dysfunctionestrogeniceye disordereye drynessfemale patientsfollowing menopausegenome mutationglaucomatousgonadal steroidshuman modelmalemenmitochondrialmitochondrial dysfunctionmitochondrial metabolismmodel of humanmouse modelmouse mutantmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyocular diseaseocular disorderocular drynessocular signs of drynessocular surface drynessolder womenophthalmopathyoxidationoxidative damageoxidative injurypast menopausepathophysiologypathwaypatients being femalepatients being womenpatients who are femalepost-menopausalpostmenopausalpostmenopausal statuspre-menopausalpremenopausal statusprotective effectreduced estrogenretinal ganglionsenile macular diseasesexsex steroidtear deficiencytransgenicultra violet lightultra violet radiationultra violet raysultraviolet lightultraviolet radiationwomen patients♀♂
Description preview
“Modulation of Corneal Endothelial Mitochondrial Activity and Dysfunction by Estrogen”
ABSTRACT
The broad long-term objective of this project is to determine if estrogen is protective or detrimental to the
health of corneal endothelial cells. Estrogen has been shown to be protective of many tissues and this protection
is lost during menopause.…
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