grant
Modulating the localization and persistence of microbial neoantigen vaccine vectors to enhance therapeutic efficacy
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AcidsAddressAffectAntineoplastic VaccineB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellB16F10BacteriaBacterial VaccinesBacterinBiodistributionBloodBlood Reticuloendothelial SystemBody TissuesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancer TreatmentCancer VaccinesCancersClonalityCytolysisCytotoxic cellDendritic cell activationDevelopmentDoseE coliE. coliEdodekin AlfaEngineeringEnvironmentEpitope spreadingEquilibriumEscherichia coliExhibitsGeneralized GrowthGeneticGrowthHomeHypoxiaHypoxicIFN-GammaIFN-gIFN-γIFNGIFNγIL-12IL12Immune Cell ActivationImmune InterferonImmune mediated therapyImmune responseImmune systemImmunologically Directed TherapyImmunotherapyInhalationInhalingInjectionsInterferon GammaInterferon Type IIInterleukin-12IntravenousK lymphocyteKnock-outKnockoutLocationLungLung Respiratory SystemLysisMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasuresMediatingMedicineMelanoma MetastasisMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic MelanomaMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LungMethodsMiceMice MammalsModelingModificationMurineMusMyeloid-derived suppressor cellsNK CellsNKSFNatural Killer Cell Stimulatory FactorNatural Killer CellsNeoplasm MetastasisNeoplasm VaccinesOxygen DeficiencyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPeptidesPersonalized medical approachPhagocytosisPlasmidsPlayPopulationPredispositionProductionRegulatory T-LymphocyteRelapseResearchResistance developmentResistant developmentRoleRouteSafetySecondary NeoplasmSecondary TumorSolid NeoplasmSolid TumorSpecificitySpleenSpleen Reticuloendothelial SystemSusceptibilitySystemT cell receptor repertoire sequencingT cell receptor sequencingT cell responseT-Cell ActivationT-CellsT-LymphocyteT8 CellsT8 LymphocytesTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTestingTherapeuticTimeTissue GrowthTissuesToxic effectToxicitiesTreatment EfficacyTregTumor ImmunityTumor TissueTumor VaccinesTumor VolumeVaccine DesignVaccinesWorkactivate T cellsanti-canceranti-cancer immunotherapyanti-cancer therapyanti-tumor immunityanti-tumor vaccineanticancer immunotherapyantigen spreadingantigen-specific T cellsantitumor immunitybacteria vectorbacterial vectorbalancebalance functioncancer immunitycancer immunotherapycancer metastasiscancer microenvironmentcancer therapycancer vaccinationcancer-directed therapyclinical applicabilityclinical applicationcomparable efficacycomparative efficacycompare efficacyconventional therapyconventional treatmentdelivery vectordelivery vehicledeveloping resistancedevelopmentaldraining lymph nodeexperiencehomeshost responseimmune activationimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenicimmunogenicityimmunoresponseimmunosuppressedimmunosuppressive myeloid cellsimmunotherapy for cancerimmunotherapy of cancerimprovedin vivoindividualized approachindividualized cancer vaccinesinsightintervention efficacylFN-Gammalung metastasismalignancymetastasize to the lungmicrobialmouse modelmurine modelmyeloid suppressor cellsmyeloid-derived suppressive cellsneo-antigenneo-antigen vaccineneo-epitopesneoantigen vaccineneoantigensneoepitopesneoplasm/cancerontogenypatient oriented outcomespersonalized anti-tumor vaccinespersonalized approachpersonalized cancer vaccinespersonalized tumor vaccinesplasmid vaccineprecision approachprecision cancer vaccinespulmonary metastasisrecruitregional lymph noderegulatory T-cellsresponsescRNA sequencingscRNA-seqside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesuppressive myeloid cellstailored approachtherapeutic effectivenesstherapeutic efficacytherapeutic outcometherapeutically effectivetherapy efficacytherapy outcomethymus derived lymphocytetumortumor cell metastasistumor growthtumor microenvironmenttumor vaccinationvaccine for cancervectorvector vaccine
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PROJECT SUMMARY
The development of neoantigen cancer vaccines is transforming cancer immunotherapy – providing an approach
to stimulate pre-existing and de novo anti-tumor T cell responses. These vaccines are designed to introduce
tumor-specific neoantigens to activate the immune system, and can be amplified through tumor lysis–mediated
epitope…
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