grant
Modulating synovial mechanobiology to mitigate disease progression in osteoarthritis
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AblationActomyosinAddressAdhesion PlaquesAgeAreaArthritisAssayBehaviorBehavior monitoringBioassayBiological AssayBiologyBiomedical EngineeringBody TissuesBone-Derived Transforming Growth FactorCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell SignalingCell secretionCell-Extracellular MatrixCell-Matrix Adherens JunctionsCellsCellular MechanotransductionCellular SecretionChronicClinicalCollagenDataDegenerative ArthritisDegenerative polyarthritisDevelopmentDevicesDiseaseDisease ProgressionDisorderDrug TherapyECMEarly InterventionElderlyEsthesiaExtracellular MatrixFibroblastsFibrosisFocal AdhesionsFocal ContactsFoundationsFutureGelGene ExpressionGene TranscriptionGenesGeneticGenetic TranscriptionGlassHarvestHistologicHistologicallyHistologyImmunofluorescenceImmunofluorescence ImmunologicIn VitroInflammationInflammation MediatorsInflammatoryInterventionIntra-Articular InjectionsIntraarticular InjectionsIntracellular Communication and SignalingJointsKnock-outKnockoutKnowledgeLabelLaboratory AnimalsLengthLoxP-flanked alleleMeasurementMeasuresMechanical Signal TransductionMechanicsMechanosensory TransductionMedial MenisciMedial meniscus structureMembrana Synovialis Capsulae ArticularisMembraneMeniscus MedialisMentorshipMethodsMiceMice MammalsMilk Growth FactorModelingModificationMorphologyMotorMurineMusMusculoskeletalMyofibroblastMyosin IIMyosin Type IIOperative ProceduresOperative Surgical ProceduresOrthopedicOrthopedic Surgical ProfessionOrthopedicsOsteoarthritisOsteoarthrosisPainPainfulPathogenesisPathologyPathway interactionsPharmacological TreatmentPharmacotherapyPhenotypePhysiciansPhysiologicPhysiologicalPlatelet Transforming Growth FactorPlayPopulationPreventionProductionProteinsRNA ExpressionRecombinantsResearchRiskRoleScientistSensationSignal TransductionSignal Transduction SystemsSignalingSourceStaining methodStainsSurgicalSurgical InterventionsSurgical ProcedureSynoviaSynovial FluidSynovial MembraneSynoviumSystems AnalysesSystems AnalysisTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticTissuesTraction Force MicroscopyTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransgenic MiceUpregulationWild Type MouseWorkadvanced ageagesarthriticbehavior observationbehavioral monitoringbehavioral observationbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionblebbistatinburden of diseaseburden of illnesscareercompare interventioncomparison interventionconditional knock-outconditional knockoutcytokinedegenerative joint diseasedevelopmentaldisabilitydisease burdendrug interventiondrug treatmentfloxedfloxed allelefunctional outcomesgeriatricgroup interventionhypertrophic arthritisin vivoinflammatory mediatorinnovateinnovationinnovativejoint degenerationjoint degradationjoint destructionjoint tissue degenerationmanage symptommechanicmechanicalmechanical stimulusmechanosensingmechanotransductionmembrane structureminimally invasivemouse modelmurine modelnano indentationnanoindentationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-muscle myosinnonmuscle myosinnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetolder adultolder adulthoodpain outcomepain-related outcomepathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspolyacrylamide gelspressurepreventpreventingscRNA sequencingscRNA-seqsenior citizensingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssmall molecular inhibitorsmall molecule inhibitorsocial rolesurgerysymptom managementtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettherapeutically effectivetissue culturetranslational opportunitiestranslational potentialtreatment grouptreatment strategywildtype mouse
Description preview
Project Summary
Nearly 8% of the global population suffers from osteoarthritis, and the burden of disease is much higher
among older adults. Current treatment strategies are limited to symptom management or require invasive
surgical procedures that carry significant risk for the elderly. Thus, there is an urgent need for minimally invasive,…
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