grant
Modulating Fibrinolysis Dynamics by Leveraging Multivalent Avidity to Control Enzyme Activity
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 15 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025Active SitesAcuteAddressAffectAffinityAlteplaseAntiplasminAntithrombotic AgentsAntithrombotic DrugsAssayAvidityBindingBinding ProteinsBioassayBiological AssayBleedingBlood ClottingBlood VesselsBlood coagulationBypassCardiac infarctionCathetersCharacteristicsClinicClottingCoagulationCoagulation ProcessComplexCytolysisDataDeep Vein ThrombosisDeep-Venous ThrombosisDiagnosisDigestionDrug TherapyEC 3.4.21.7ELISAEnzyme GeneEnzyme InhibitionEnzyme-Linked Immunosorbent AssayEnzymesFibrinFibrinolysesFibrinolysinFibrinolysisFibrinolytic AgentsFibrinolytic DrugsFibrinolytic TherapyFutureGlu-PlasminGoalsHemorrhageHemostasisHemostatic functionHomoHumanIn VitroInfusionInfusion proceduresInjuryInterventionIntracranial HemorrhagesIschemic StrokeKnowledgeKringle DomainsKringlesLabelLeadLengthLigand Binding ProteinLigand Binding Protein GeneLinkLysisModern ManMolecularMolecular InteractionMyocardial InfarctMyocardial InfarctionPathogenicityPatientsPb elementPersonsPharmacological TreatmentPharmacotherapyPlasminPlasmin AntiactivatorPlasmin InhibitorPlasminogenPredictive FactorProfibrinolysinProtease FProtein BindingProteinsPulmonary EmbolismRecombinant Tissue Plasminogen ActivatorRecurrenceRecurrentRegulatory ProteinResearchRiskSafetySchemeSerpinsStandardizationSurfaceSystemT-Plasminogen ActivatorTherapeuticTherapeutic InterventionTherapeutic ThrombolysisThermodynamicThermodynamicsThrombolytic AgentsThrombolytic DrugsThrombolytic TherapyTimeTissue Activator D-44Tissue Plasminogen ActivatorTissue-Type Plasminogen ActivatorTranslatingTranslationsWhole Bloodactive controlalpha 2-Glucoproteinsalpha 2-Macroglobulinalpha 2-Plasmin Inhibitoralpha-2-Antiplasminalpha2-Macroglobulinantithrombotic medicationantithromboticsblood lossbound proteincardiac infarctclinical translationclinically translatablecoronary attackcoronary infarctcoronary infarctiondrug interventiondrug treatmentenzyme activityenzyme linked immunoassayenzyme substrateexperimentexperimental researchexperimental studyexperimentsgenetic regulatory proteinheart attackheart infarctheart infarctionheavy metal Pbheavy metal leadimprovedin vivoinfusionsinhibitorinjuriesintervention therapyischemic limblimb ischemiamouse modelmurine modelnano particlenano-sized particlenanoparticlenanosized particlenew approachesnovelnovel approachesnovel strategiesnovel strategypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsregulatory gene productstandard of caret-PAtranslationtranslational opportunitiestranslational potentialvascularvenous thromboembolismα2-Macroglobulinα2m
Description preview
PROJECT SUMMARY
Blood clots kill more humans than any other single pathogenic cause. A new or recurrent diagnosis of venous
thromboembolism (VTE), which encompasses both pulmonary embolism (PE) and deep vein thrombosis
(DVT), affects >900,000 people each year in the US alone. Current PE standard of care includes the delivery
of acute clot…
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