grant
Modulating cortical inhibitory networks to improve stroke recovery
Organization VETERANS AFFAIRS MED CTR SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Sept 2023Deadline 31 Aug 2028
VANIHUS FederalResearch GrantFY2025AddressAdmissionAdmission activityAffectAnimalsApoplexyAreaBrainBrain Nervous SystemBrain Vascular AccidentCaM KIICaM PK IICaM kinase IICaMKIICalciumCell BodyCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClinical TrialsComplexDataDysfunctionElectronic Medical Records and Genomics NetworkEncephalonEnsureEnvironmentExperimental DesignsFunctional disorderFutureGoalsGripsHospitalsInvestigationInvestigatorsLaboratoriesLearningLeftLong-term disabilityMentorshipModificationMotor CortexMovementNerve CellsNerve UnitNeural CellNeurocyteNeuronsPatientsPatternPhysiciansPhysiopathologyPopulationPopulation DynamicsPreparationProgram DevelopmentPublicationsRandomizedReaction TimeRecoveryReproducibilityResearchResearch PersonnelResearchersResponse RTResponse TimeSan FranciscoScientific PublicationScientistStrokeSystemTestingTrainingTranslatingVeteransafter strokebody movementbrain attackcalcium-dependent CaM kinase IIcalmodulin-dependent protein kinase IIcareer developmentcell cortexcell typecerebral vascular accidentcerebrovascular accidentcohortdesigndesigningdisabilityeMERGE ConsortiumeMERGE Networkexcitatory neuronexperienceexperimentexperimental researchexperimental studyexperimentsfunctional improvementgraspimaging systemimprove functionimprovedimproved functional outcomesimproved motor functioninhibitory neuroninjury recoveryinsightkinematic modelkinematicslocomotor learninglong-term recoverymotor behaviormotor function improvementmotor learningmotor recoveryneural circuitneural circuitryneural controlneural regulationneurocircuitryneuromodulationneuromodulatoryneuronalneurophysiologicalneurophysiologyneuroregulationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoptogeneticspathophysiologypost strokepoststrokepreparationsprogramspsychomotor reaction timerandomisationrandomizationrandomly assignedrecovery after injuryrecovery following injuryrecovery post injuryrecruitsexskillsstroke patientstroke recoverystroke therapystroke treatmentstrokedstrokessupport networksynaptic circuitsynaptic circuitrytooltreating stroke
Description preview
The overarching goal of this project is to identify new targets for neural circuit modulation to
facilitate motor recovery after stroke. To accomplish this, I propose to identify how dynamics in a
specific inhibitory cell network participates in motor learning, investigate how these dynamics are
disrupted by stroke, and test whether their…
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