grant
Modeling and Characterizing the Genomic Consequences of MED12 Mutations in Uterine Fibroids
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DATAC sequencingATAC-seqATACseqAgeAmino AcidsAminoacetic AcidAssay for Transposase-Accessible Chromatin using sequencingAutomobile DrivingAuxinsBiologic ModelsBiological ModelsBiologyCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCell BodyCell LineCell modelCellLineCellsCellular modelClustered Regularly Interspaced Short Palindromic RepeatsCodonCodon NucleotidesCommunicationCommunitiesComparative StudyComplementComplement ProteinsDNA mutationDevelopmentDiseaseDisorderEmotional StressEngineeringExonsFibroblastsFibroidFibroid NeoplasmFibroid TumorFibroid UterusFibromyomaFinancial HardshipGene TranscriptionGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGenomicsGlycineGoalsHealthHumanHysterectomyIn VitroLeiomyocyteLeiomyomaLeiomyomatous NeoplasmLeiomyomatous TumorMediatorMetabolicMiceMice MammalsModel SystemModelingModern ManMolecularMurineMusMuscle NeoplasmsMuscle TumorMutateMutationMyomatous TumorMyomatous neoplasmMyometrialNatureNon-MalignantOncogenesisPathway interactionsPatientsPhenotypePopulationPositionPositioning AttributePrimary NeoplasmPrimary TumorProteinsPublishingRNA ExpressionRecurrenceRecurrentRegulationRoleSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSocietiesSomatic MutationStrains Cell LinesStromal CellsSystemTechnologyTestingTherapeuticTranscriptionTranscription AlterationUterine Body FibroidUterine Body LeiomyomaUterine Corpus FibroidUterine Corpus LeiomyomaUterine FibroidsUterine FibromaUterine LeiomyomaUterusUterus FibromaWomanagesaminoacidassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingblack femaleblack womencellular developmentchemical librarychildbearing ageclinical relevanceclinically relevantclustered regularly interspaced short palindromic repeats screencomplementationcorpus uteri fibroidcorpus uteri leiomyomacultured cell linedevelopmentaldiscover genesdriver lesiondriver mutationdrivingdruggable targeteffective therapyeffective treatmentfertile agefinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial strainfinancial stressgene discoverygene regulatory networkgenome mutationimprovedin vivomolecular phenotypemultiomicsmultiple omicsmutantmutational statusnonmalignantpanomicspathwayprogenitorprogramsproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialreproductive agereproductive yearsscreeningscreeningssmall molecule librariessocial rolesomatic varianttherapeutic targetthree dimensionaltreatment strategytumortumorigenesisuterus leiomyomawomb
Description preview
ABSTRACT
Uterine fibroids (leiomyomas) are the most widely observed tumors in women. By age 50, more than ~70% of
white and more than 80% of black women develop at least one UF tumor. Although non-malignant, they disrupt
normal uterine function and cause severe health problems ~25% of reproductive-age women. The most common
subtype, representing…
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