grant
Mitochondrial signaling dynamics in cocaine use disorder
Organization RESEARCH TRIANGLE INSTITUTELocation RESEARCH TRIANGLE PARK, UNITED STATESPosted 15 Aug 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AbscissionActive OxygenAdenosine TriphosphateAdenylpyrophosphateAxon TerminalsBehaviorCRISPRCRISPR/Cas systemCalciumCardiolipinsCell Communication and SignalingCell SignalingChemistryClustered Regularly Interspaced Short Palindromic RepeatsCocaineCocaine use disorderComplexDA NeuronDopamine neuronDrug TargetingDrugsEnzyme GeneEnzymesErythrocupreinEventExcisionExtirpationFiberFutureGenerationsGenesH2O2HealthHemocupreinHydrogen PeroxideHydroperoxideIntracellular Communication and SignalingKnock-outKnockoutLeadMeasuresMedicationMiceMice MammalsMitochondriaMitochondrial MatrixMitochondrial ProteinsMonitorMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology - biologic functionNucleus AccumbensOxygen RadicalsPb elementPharmaceutical PreparationsPharmacologyPhosphatidesPhospholipidsPhotometryPresynaptic Nerve EndingsPresynaptic TerminalsPro-OxidantsProductionProteinsReactive Oxygen SpeciesRemovalResearchSignal TransductionSignal Transduction SystemsSignalingSpecificityStimulant overdoseSubstance Use DisorderSuperoxide AnionSuperoxide DismutaseSuperoxide RadicalSuperoxidesSurgical RemovalSynapsesSynapticSynaptic BoutonsSynaptic TerminalsSystemTestingTherapeuticViralabused drugabused drugsawakebiological signal transductioncalcium uniportercocaine exposurecocaine-exposedcytocupreindopaminergic neurondrug abuseddrug of abusedrug/agentdrugs abuseddrugs of abuseexposed to cocaineexposure to cocaineheavy metal Pbheavy metal leadin vivoknockout genemitochondrialmitochondrial based therapeuticsmitochondrial targeted therapeuticsmitochondrial therapeuticsmitotherapeuticsneural functionneuronalnoveloverdose deathoverdose fatalitiespharmacologicpsychostimulant overdoseresectionresponsesensorsubstance use and disordersynapsetool
Description preview
PROJECT SUMMARY
Cocaine use disorder continues to be a significant health burden, with psychostimulant overdose
deaths rising significantly over the past few years. Cocaine exposure can alter aspects of mitochondrial
function, but the tools to access and manipulate mitochondria in vivo are limited. Mitochondria contribute a
significant amount of…
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