grant
mitochondrial DNA leakage promotes inflammation and intervertebral disc degeneration
Organization NORTHEAST OHIO MEDICAL UNIVERSITYLocation ROOTSTOWN, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY202521+ years oldActive OxygenAddressAdultAdult HumanAffectAgeAmericanAnalgesia TestsBacteriaBeta Proprotein Interleukin 1BiomechanicsCartilageCartilaginous TissueCell BodyCell DeathCellsChronicCommon Rat StrainsCyclic GMPCytosolDNADNA DamageDNA InjuryDeoxyribonucleic AcidDeteriorationDiseaseDisorderDouble-Stranded DNADysfunctionElectron TransportExposure toExtracellular Matrix DegradationExtravasationFemaleFunctional disorderGender BiasGene ActivationGene ExpressionGenesGoalsGuanosine Cyclic MonophosphateH2O2HealthHealth ExpendituresHumanHydrogen PeroxideHydroperoxideIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImpairmentIn VitroInflammationInflammatoryInflammatory ResponseInterleukin 1betaInterleukin-1 betaInterleukin-1βIntervertebral Disc Degenerative DiseaseIntervertebral Disc Degenerative DisorderIntervertebral DiskIntervertebral disc structureKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLeakageLow Back AcheLow Back PainLow BackacheLumbagoMacromolecular Protein ComplexesMiceMice MammalsMitochondriaMitochondrial DNAModelingModern ManMultiprotein ComplexesMurineMusMutant Strains MiceNatureNeedlesNociception TestsNuclearNull MouseOperative ProceduresOperative Surgical ProceduresOxidative StressOxygen RadicalsPainPain AssessmentPain MeasurementPain measurePainfulPathologicPathologyPathway interactionsPhysiopathologyPlayPolymerasePredispositionPreinterleukin 1 BetaPro-OxidantsProductionPublishingPuncture procedurePuncturesRatRats MammalsRattusReactive Oxygen SpeciesRoleSamplingSeveritiesSex BiasSpillageSpinal ColumnSpineSterilityStimulator of Interferon GenesSurgicalSurgical InterventionsSurgical ProcedureSusceptibilitySystemTestingTimeTraumaVertebral columnadulthoodagesbackbonebiomechanicalcGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcGMPcostcyclic GMP-AMP synthase/STINGcyclophilin Dcyclophilin-40cyclosporin A-SPTPcyclosporin A-sensitive pereability transition poredegenerated intervertebral discdegenerative disc diseasedisc degenerationds-DNAdsDNAelectron transferendonucleaseendosymbionthealth care expenditureimprovedin vivoinhibitorintervertebral disk degenerationknock-downknockdownmalemedical expendituremitochondrialmitochondrial DNA mutationmitochondrial megachannelmitochondrial membranemitochondrial permeability transition poremouse modelmouse mutantmtDNAmtDNA mutationmurine modelmutantnecrocytosisnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoxidationoxidative damageoxidative injurypain assaypathophysiologypathwaypharmacologicsmall moleculesocial rolesterilesurgery♀♂
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Description preview
Intervertebral disc (IVD) degeneration (IDD) is a major cause of low back pain, affecting 39% of American adults
over the age of 18 and costing $87.6 billion in estimated healthcare expenditure. IDD is characterized by
structural and functional deterioration, extracellular matrix degradation, oxidative stress, sterile inflammation,
and impaired…
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