grant
Mitochondria mediated intercellular metabolic coupling in bone marrow regeneration
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 1 Jul 2020Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase2-Keto-4-Hydroxyglutarate Dehydrogenase2-Oxoglutarate Dehydrogenase2-Oxoglutarate Dehydrogenase Complex5'-AMP-activated protein kinase5'-Adenylic acidAMP-activated kinaseAMP-activated protein kinaseAMPK enzymeAdenosine MonophosphateAdenylic AcidAdventitial CellAreaAssayBM Stem CellBM derived progenitorBM progenitorBM- derived Stem CellsBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBioassayBiological AssayBiologyBlood DiseasesBlood Precursor CellBlood VesselsBone MarrowBone Marrow PurgingBone Marrow Reticuloendothelial SystemBone Marrow Stem CellBone Marrow Stem Cell TransplantationBone Marrow progenitorBone RegenerationBone marrow-derived mesenchymal stem cellsCalciumCell BodyCell CommunicationCell InteractionCell-to-Cell InteractionCellsChimerismClinicClosure by LigationCommunicationComplexConditioning TherapyConnexin 43Connexin43ConnexinsCouplingCx43DNA TherapyDNA mutationDataElectron TransportEvolutionFailureFunctional RegenerationFundingGap Junction ProteinsGene Transfer ClinicalGenetic ChangeGenetic InterventionGenetic defectGenetic mutationGoalsHMG CoA reductase (NADPH) kinaseHMG CoA reductase kinaseHMG coenzyme A reductase (NADPH) kinaseHSC transplantationHematologic DiseasesHematological DiseaseHematological DisorderHematologyHematopoiesisHematopoieticHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationHematopoietic stem cellsImpairmentInterventionInvestigationKetoglutarate Dehydrogenase ComplexKinasesLigationMediatingMesenchymalMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMetabolicMethodsMitochondriaMolecularMolecular TargetMutationNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNatural regenerationOxoglutarate DehydrogenasePathologicPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPericapillary CellPericytesPerivascular CellPhosphotransferase GenePhosphotransferasesPoliciesPrincipal InvestigatorProductionProgenitor CellsProtocolProtocols documentationPublishingPurine ReceptorsPurinergic ReceptorsPurinoceptorRecoveryRegenerationRegenerative MedicineRegulationResearchRoleRouget CellsSignal PathwayStressSystemTransphosphorylasesTransplantationUpregulationWorkWritingalpha-Ketoglutarate Dehydrogenasealpha-Ketoglutarate Dehydrogenase Complexbehavior interventionbehavioral interventionblood cell formationblood cell progenitorblood disorderblood progenitorblood stem cellblood stem cell transplantationblood-forming stem cellbone marrow derived progenitorbone marrow derived stem cellsbone marrow mesenchymal progenitorbone marrow mesenchymal stem cellbone marrow stromal cellbone marrow stromal stem cellcell regenerationcellular regenerationchemotherapyconditioningelectron transferexperimentexperimental researchexperimental studyexperimentsgene repair therapygene therapygene-based therapygenetic therapygenome mutationgenomic therapyhematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic engraftmenthematopoietic progenitorhematopoietic progenitor cell transplantationhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellhydroxymethylglutaryl-CoA-reductase kinaseimprovedin vivoinhibitorinterestirradiationloss of functionmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmitochondrialmitochondrial dysfunctionmutantmyeloablationnovelpatient oriented outcomespharmacologicpost-transplantpost-transplantationposttransplantposttransplantationpreservationpreventpreventingprogenitor cell regenerationprogenitor cell self renewalprogenitor regenerationprogenitor self renewalprogramsregenerateregenerate boneregenerativesensorsocial rolestemstem and progenitor cell regenerationstem and progenitor cell self renewalstem cell bone marrow transplantationstem cell regenerationstem cell self renewalstem cellstranslation strategytranslational approachtranslational opportunitiestranslational potentialtranslational strategytransplantvascular
Description preview
Abstract
Hematopoietic stem cell (HSC) transplantation (HSCT) after conditioning is widely used in the
clinic to treat pathological mutations in the lympho-hematopoietic system. The mechanisms on
how the bone marrow (BM) microenvironment (ME) and transplanted HSC interact remains a
mystery in biology. Understanding the underpinning mechanisms…
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