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Mitochondria and anesthetic-induced developmental neurotoxicity
Organization MEDICAL COLLEGE OF WISCONSINLocation MILWAUKEE, UNITED STATESPosted 1 Sept 2023Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY20250-11 years oldAcute Brain InjuriesAddressAgeAnesthesiaAnesthesia proceduresAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsAnimalsAreaBehaviorBehavioralCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell Communication and SignalingCell DeathCell SignalingCessation of lifeChildChild YouthChildren (0-21)Clustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalDataDeathDisturbance in cognitionEpidemiologyFood and Drug AdministrationFunctional RNAGeneral AnestheticsGeneral anesthetic drugsGenesGoalsHumanImpaired cognitionImpairmentInjuryIntracellular Communication and SignalingInvestigationKnowledgeLinkMediatingMiceMice MammalsMitochondriaModern ManMolecularMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeurosciencesNoncoding RNANontranslated RNAOperative ProceduresOperative Surgical ProceduresPathway interactionsPost-Transcriptional ControlPost-Transcriptional RegulationProblem behaviorPublic HealthResearchSignal TransductionSignal Transduction SystemsSignalingSurgicalSurgical InterventionsSurgical ProcedureTransgenic MiceUSFDAUnited States Food and Drug AdministrationUntranslated RNAagesaxon signalingaxon-glial signalingaxonal signalingbehavioral problembiological signal transductionbrain cellcell typecognitive defectscognitive dysfunctioncognitive lossdevelopmental neurotoxicityepidemiologicepidemiologicalgain of functionglia signalingglial signalinghiPSChigh throughput analysishuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsinduced human pluripotent stem cellsinjuriesinnovateinnovationinnovativekidsloss of functionmitochondrialmitochondrial dysfunctionmouse modelmulti-photonmultiomicsmultiple omicsmurine modelnecrocytosisnerve signalingneural signalingneuron toxicityneuronalneuronal signalingneuronal toxicityneuroprotectionneuroprotectiveneurotoxicneurotoxicityneurotransmissionnoncodingnovelpanomicspathwaypost-transcriptional gene regulationpreventpreventingprogenitor cell modelprogenitor modelprogramsreal-time imagesrealtime imagescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall moleculestem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelsurgerytherapeutically effectivetoolyoungster
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PROJECT SUMMARY
Millions of children receive general anesthetics (GAs) for surgical procedures. Emerging evidence from human
epidemiologic and animal studies suggest that short acting general anesthetic drugs can cause acute brain
injury, leading to long-term cognitive defects and behavioral problems. In 2016, the US Food and Drug
Administration…
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