grant
Mitigator Efficacies after Realistic Improvised Nuclear Device (IND) Exposure: MERIE
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 26 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Academic Medical CentersAddressAnimal ModelAnimal Models and Related StudiesAnimalsArkansasBiologicalBiological MarkersBody TissuesCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCommon Rat StrainsConventional X-RayCoupledDataData AnalysesData AnalysisDevicesDose RateEffectivenessEnsureExperimental DesignsExposure toFDA approvedFundingGovernmentGrantHeart VascularKidneyKidney Urinary SystemLaboratoriesLeadLinkLisinoprilLung damageMeasurementMedicalMonitorNIAIDNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthNeutronsNuclearNuclear WeaponPb elementPerformancePharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePolypharmacyPrinivilProbabilityPublicationsR-Series Research ProjectsR01 MechanismR01 ProgramRadiationRadiation DoseRadiation Dose UnitRadiation exposureRatRats MammalsRattusResearchResearch GrantsResearch Project GrantsResearch ProjectsResearch SupportRoentgen RaysSamplingScienceScientific PublicationScientistSeriesSimvastatinSourceStandardizationSurvivorsSyndromeSynvinolinTestingTimeTissuesTrainingUnited States National Institutes of HealthUniversitiesUniversity Medical CentersWisconsinX-RadiationX-Ray ImagingX-Ray Medical ImagingX-Ray RadiationX-rayXrayXray imagingXray medical imagingZestrilbio-markersbiologicbiologic markerbiomarkercardiac damagecirculatory systemcohortconventional Xraydamage to kidneydata interpretationdesigndesigningdosimetrydrug repositioningdrug repurposingexperienceheart damageheavy metal Pbheavy metal leadimprovedinterestirradiationkidney damagelung injurymedical collegemedical schoolsmodel of animalmultidisciplinarymultiorgan damagepharmaceuticalprogramspulmonarypulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryradiation countermeasureradiation effectradiation mitigatorradiological countermeasureradiological mitigatorradiomitigatorrenalrenal damagerepurposing agentrepurposing medicationschool of medicinestatisticsstemtool
Description preview
The need for improved radiation effect mitigators stems from the significant probability of the detonation of an
Improvised Nuclear Device (IND). Typically pharmaceutical radiation countermeasures have been tested
against x rays delivered over a few minutes. In practice, however, 1) the majority of the IND-related radiation
dose will be delivered…
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