grant
Mitigation of Cerebral Infarct Growth in Acute Ischemic Stroke Using a Novel Blood Substitute
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AbscissionAccident and Emergency departmentAcquired brain injuryAcuteAddressAffectAgingAmbulancesAnemiaAnimal ModelAnimal Models and Related StudiesAnimalsAntiinflammatory EffectAntithrombotic AgentsAntithrombotic DrugsApoplexyAreaArteriesArtificial BloodArtificial ErythrocytesBiological AgentBiological MarkersBiological ProductsBloodBlood Reticuloendothelial SystemBlood SubstitutesBlood VesselsBlood flowBody TissuesBovine SpeciesBrainBrain Hypoxia-IschemiaBrain InfarctionBrain InflammationBrain InjuriesBrain Nervous SystemBrain Vascular AccidentBrain regionBranch HospitalsCarbomonoxyhemoglobinCarbon MonoxideCarbonmonoxyhemoglobinCarbonylhemoglobinCarboxyhemoglobinCattleCell BodyCellsCentral venous pressureCerebral HypoxiaCerebral InfarctionCerebral StrokeCerebral Tissue HypoxiaCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular StrokeCerebrumClinical TrialsClottingCoagulationCoagulation ProcessComplexDWI (diffusion weighted imaging)DWI-MRIDeveloped CountriesDevelopmentDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderDoseDropsyDysfunctionEdemaEffectivenessEmbolectomyEmergency DepartmentEmergency roomEncephalitisEncephalonEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideErythrocyte SubstitutesExcisionExtirpationFibrinolytic AgentsFibrinolytic DrugsFunctional disorderFutureGeneralized GrowthGenerationsGoalsGrowthHemoglobinHospitalsHumanHydropsHypoxiaHypoxicImageIndustrialized CountriesIndustrialized NationsInfarctionInflammationInfusionInfusion proceduresInjuryInterventionIschemiaIschemia-Reperfusion InjuryIschemic StrokeLeptomeningesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMicrobeadsMicrospheresMiddle Cerebral Artery OcclusionMisonidazoleModelingModern ManMononitrogen MonoxideNMR ImagingNMR TomographyNatural HistoryNeedlesNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuroprotectantsNeuroprotective AgentsNeuroprotective DrugsNeutronsNitric OxideNitrogen MonoxideNitrogen ProtoxideNuclear Magnetic Resonance ImagingO elementO2 elementOutcomeOxygenOxygen DeficiencyPETPET ScanPET imagingPETSCANPETTPartial PressurePatientsPerfusionPersonsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhysiopathologyPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyProceduresProcessRad.-PETRed Cell SubstitutesRemovalReperfusion DamageReperfusion InjuryReperfusion TherapyRoentgen RaysSafetySatellite HospitalsStrokeSurgical RemovalSymptomsSystemTestingThrombolytic AgentsThrombolytic DrugsTimeTissue GrowthTissuesTriageVasodilatationVasodilationVasorelaxationWorkX-RadiationX-Ray RadiationX-rayXrayZeugmatographyanti-inflammatory effectantithrombotic medicationantithromboticsbio-markersbiologic markerbiologicsbiomarkerbiopharmaceuticalbiotherapeutic agentblood flow in brainblood productbovidbovinebrain attackbrain blood circulationbrain blood flowbrain cellbrain damagebrain infarctbrain-injuredcanine animal modelcanine modelcarbonyl-hemoglobinscerebralcerebral blood flowcerebral circulationcerebral infarctcerebral vascular accidentcerebrocirculationcerebrovascular accidentcerebrovascular blood flowcompare to controlcomparison controlcowdMRIdesigndesigningdetermine efficacydeveloped countrydeveloped nationdeveloped nationsdevelopmentaldiffuseddiffusesdiffusingdiffusion tensor imagingdiffusionsdisabilitydog modelefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationendothelial cell derived relaxing factorevaluate efficacyexamine efficacyexperimentexperimental researchexperimental studyexperimentsextracellularfeedinghypoxia/ischemiaimagingimprovedimproved outcomeinfarctinfusionsinjuriesischemia injuryischemic injurylongitudinal imagingmiddle cerebral arterymodel of animalneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenypathophysiologypharmaceuticalpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpreclinicalpreservationpreventpreventingrecruitreperfusionresectionserial imagingside effectstroke modelstroke therapystroke treatmentstrokedstrokestreating stroketreatment effectvascularvascular constrictionvasoconstrictionvasogenic edema
Description preview
Project Summary/Abstract
The aging of the population in industrialized nations is increasing the number of ischemic strokes that present in
the emergency rooms of hospitals. In the ischemic stroke neurons die rapidly (estimated at 1 million neurons per
minute) prompting the need for rapid triage and treatment to open the blocked blood vessel. We…
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