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Mitigating ADA Through Site-specific Conjugation Technology

Organization STATE UNIVERSITY OF NY,BINGHAMTONLocation BINGHAMTON, UNITED STATESPosted 21 Nov 2022Deadline 16 May 2025 ⚠️
NIHUS FederalResearch GrantFY2025AchievementAchievement AttainmentAffectAffinityAgonistAllergic ReactionAntibodiesAntibody ResponseAntibody-drug conjugatesAntigen-Presenting CellsAreaAssayAttenuatedB7-1BB1BindingBioassayBiologicalBiological AssayCD28LGCD28LG1CD80CD80 geneCD86CD86 geneCancer TreatmentCell BodyCellsCysteineDataDevelopmentDifferentation MarkersDifferentiation AntigensDifferentiation MarkersDoseDrug DeliveryDrug Delivery SystemsDrugsELISAEngineeringEnzyme GeneEnzyme-Linked Immunosorbent AssayEnzymesExhibitsF elementFDA approvedFc domainFluorescenceFluorineFundingGoalsHalf-CystineHydrophobicityIgG1ImmuneImmunesImmunoactivatorsImmunoadjuvantsImmunologic AdjuvantsImmunologic StimulationImmunological StimulationImmunooncologyImmunopotentiatorsImmunostimulantsImmunostimulationIncidenceL-CysteineLAB7LocationMacrophageMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMarker AntigensMasksMeasurableMediatingMedicationMetabolic GlycosylationMethodsMiceMice MammalsModelingMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMurineMusMφNational Institutes of HealthOregonOregon Green 488 carboxylic acidOregon green 488PatientsPeptidesPharmaceutical PreparationsPositionPositioning AttributeProteinsPublishingReactionReportingRiskSamplingSiteTLR7TLR7 geneTechnologyTherapeuticToll-Like Receptor 7Tumor TissueUnited States National Institutes of HealthVisualizationaccessory cellanti-cancer therapyantibody conjugateattenuateattenuatesbiologicbiophysical equipmentbiophysical toolscancer therapycancer-directed therapyclinical applicabilityclinical applicationconformationconformationalconformational stateconformationallyconformationscytotoxicdesigndesigningdevelopmentaldrug clearancedrug/agentenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsglycosylationimaging systemimmune-oncologyimmuno oncologyimmunogenicityimmunology oncologyinterestlive cell imagelive cell imaginglive cellular imagelive cellular imagingoncoimmunologypreventpreventingtooltumoruptake

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Description preview

Summary:
Antibody drug conjugate (ADC) immunogenicity is a growing concern due to the increased interest in immune-
stimulating drug delivery technology. A recent study by Novartis demonstrated that 14 out of 14 patients dosed
with an experimental immune-stimulatory ADC developed a measurable anti-drug antibody (ADA) response.
ADA negatively…

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