grant
MimicMaker: an integrated platform for identifying relevant mimics of T cell antigens
Organization UNIVERSITY OF NOTRE DAMELocation NOTRE DAME, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAI AugmentedAI assistedAI drivenAI enhancedAI integratedAI poweredAcademiaAccelerationAcute GVHDAcute Graft Versus Host DiseaseAdaptive Immune SystemAddressAdoptionAmino AcidsAntigenic DeterminantsAntigensAreaArtificial Intelligence enhancedAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIAutoimmune StatusAutoimmunityAutoregulationBenefits and RisksBindingBinding DeterminantsBiologic ModelsBiologicalBiological AgentBiological ModelsBiological ProductsBiological Response Modifier TherapyBiological TherapyBiophysicsBypassCancersCell Mediated ImmunologyCell TherapyCell-Mediated ImmunityCellular ImmunityClass II AntigensClass II Major Histocompatibility AntigensClinicalClone CellsCollaborationsCommunicable DiseasesComplicationDataData ScienceDevelopmentDisparateEngineered GeneEpitopesEvaluationEvolutionGenetic Data BanksGenetic Data BasesGenetic DatabanksGenetic DatabasesGenetic Information DatabasesGraft RejectionGrafting ProcedureHealthHistocompatibility Antigens Class IIHistocompatibility ComplexHistocompatibility ComplicesHomeostasisI-A AntigenIa AntigensIa-Like AntigensImmune DiseasesImmune DisordersImmune DysfunctionImmune Response AntigensImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune TargetingImmune mediated therapyImmune-Response-Associated AntigensImmunityImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologically Directed TherapyImmunologyImmunotherapyIndividualIndustryInfectionInfectious DiseasesInfectious DisorderInformaticsInterventionLigandsMHC Class II MoleculeMHC Class II ProteinMHC ReceptorMHC class II antigenMajor Histocompatibility ComplexMajor Histocompatibility Complex Class IIMajor Histocompatibility Complex ReceptorMajor Histocompatibility ComplicesMalignant NeoplasmsMalignant TumorMedicalMedicineModel SystemMolecularMolecular InteractionMolecular MimicryMorbidityOncologyOncology CancerOrgan TransplantationOrgan TransplantsPathogenicityPatternPeptidesPhysiological HomeostasisPrecision therapeuticsPreclinical TestingProcessProductivityProteinsReceptors, Antigen, T-Cell, alpha-betaRiskSideSpecificityStructural ModelsStructureSystemT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Antigen ReceptorsT-Cell EpitopesT-Cell ReceptorT-CellsT-LymphocyteT-Lymphocyte EpitopesT-cell therapeuticsT-cell transfer therapyTcR alpha-betaTcR αβTestingToxic effectToxicitiesTransplant RejectionTransplantationTransplantation RejectionVariantVariationVirusWorkacquired immune systemacute graft vs host diseaseacute graft vs. host diseaseadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyalpha-beta T-Cell Receptoraminoacidarmartificial intelligence assistedartificial intelligence augmentedartificial intelligence drivenartificial intelligence integratedartificial intelligence poweredbiologicbiological therapeuticbiological treatmentbiologically based therapeuticsbiologicsbiopharmaceuticalbiophysical foundationbiophysical principlesbiophysical sciencesbiotherapeutic agentbiotherapeuticsbiotherapycell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular targetingcellular therapeuticcellular therapycommercializationcross reactivitydeep learningdeep learning based modeldeep learning methoddeep learning modeldeep learning strategydevelopmentalengineered T cellsenhanced with AIenhanced with Artificial Intelligenceexperiencegenetically engineered T-cellsimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimprovedimproved outcomein silicoindividualized cancer therapymalignancymimicrymouse modelmurine modelneoplasm/cancernew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachorgan allograftorgan graftorgan rejectionorgan transplant rejectionorgan xenograftpathogenpersonalized cancer therapypersonalized cancer treatmentpersonalized immunotherapypre-clinical testingprecision immunotherapyprecision therapiesprecision treatmentpreventpreventingprospectiveprotein complexresponserisk mitigationrisk stratificationstratify risksuccesstechnology platformtechnology systemtherapeutic T-cell platformthree dimensionalthymus derived lymphocytetransgenic T- cellstranslational immunologytranslational impacttransplantαβ T-Cell Receptor
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SUMMARY
Advances in immunology are revolutionizing medicine. The last 10-20 years have seen the rapid development
of a range of transformative immunotherapies, with numerous others on the horizon, including new precision and
personalized therapies for cancer and infectious disease. Advances in immunology are also powering new ways
to address…
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