grant
MiMA: Mother-infant Metabolite-transporter Atlas
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 17 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years oldAtlasesAutoregulationBindingBiologic ModelsBiological ModelsBiologyBlood - brain barrier anatomyBlood-Brain BarrierBody TissuesBreast MilkBreastmilkChildChild YouthChildren (0-21)CommunicationDevelopmentDiseaseDisorderDrug or chemical Tissue DistributionDrugsEnsureHealthHemato-Encephalic BarrierHomeostasisHumanHuman MilkHuman Mother's MilkIndividualInfantInfrastructureKnowledgeLactationMammary Gland MilkMammary glandMapsMedicationMembraneMetabolite InteractionMilkModel SystemModern ManMolecularMolecular InteractionMother's MilkMothersNutrientOrganPatternPersonal SatisfactionPharmaceutical PreparationsPhysiological HomeostasisPhysiologyProcessProteomicsReagentResearchResearch ResourcesResourcesSpecificityStructureSystemSystems IntegrationTissue DistributionTissuesVHHVHH antibodyXenobioticsbloodbrain barriercamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaindevelopmentaldiet supplementdietary supplementsdrug/agentfetalfetal bloodgut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghuman diseaseinnovateinnovationinnovativeinsightintegrated systemintimacyintimate behaviorkidslactatinglactationalmaternal milkmembrane structuremetabolism measurementmetabolomicsmetabonomicsnanobodiesnanobodynovelnutritional supplementprecision medicineprecision nutritionprecision-based medicinesdAbsingle domain antibodiessmall moleculestructural biologysystem integrationuptakevariable heavy chain antibodywell-beingwellbeingyoungster
Description preview
ABSTRACT/SUMMARY
The maternal-fetal/infant axis of transport represents one of, if not the highest duration and intimacy of
long-distance communication across multi-tissue barriers between two individuals. Transporters enable such
communication by controlling the uptake and distribution of metabolites across membranes, tissues, organs, and
even…
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