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Microbiome-Mitochondrial Interactions Driving Cancer-Induced Cachexia in the Obese State
Organization UNIVERSITY OF SOUTH CAROLINA AT COLUMBIALocation COLUMBIA, UNITED STATESPosted 1 Sept 2024Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025AbscissionActivities of Daily LivingActivities of everyday lifeAssayAutomobile DrivingAutoregulationAwardBasal Transcription FactorBasal transcription factor genesBehaviorBioassayBiogenesisBiological AssayCachecticCachexiaCalciumCancer CachexiaCancer InductionCancer ModelCancer PatientCancer TreatmentCancerModelCancersCause of DeathDataDevelopmentDevelopment PlansDiseaseDisorderDysfunctionEnzyme GeneEnzymesEpidemiologyExcisionExtirpationFellowshipFunctional dependenceFunctional disorderGI microbiomeGI microbiotaGastrointestinal microbiotaGeneral Transcription Factor GeneGeneral Transcription FactorsGoalsHomeostasisIatrogenic CancerImpairmentInstitutionIntermediary MetabolismInterventionIntervention StrategiesInvestigatorsKnowledgeLeannessLewis Lung CarcinomaLinkLiteratureMaintenanceMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasuresMetabolicMetabolic PathwayMetabolic ProcessesMetabolic Protein DegradationMetabolismMiceMice MammalsMicrobeMitochondriaModelingMorbidityMorbidity - disease rateMorphologyMurineMusMuscle FibersMuscle MitochondriaMuscle functionMyotubesObese MiceObesityObesity associated cancerObesity related cancerOrigin of LifeOver weightOverweightOxidation-ReductionPathogenesisPathologyPatientsPhasePhenotypePhysiological HomeostasisPhysiopathologyPopulationPreventionProtein TurnoverPublishingQOLQuality ControlQuality of lifeRedoxRegulatory Protein DegradationRemovalReportingResearchResearch PersonnelResearch Project SummariesResearchersRhabdomyocyteRoleSarcosomesSeveritiesSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSurgical RemovalTechnical ExpertiseTestingTherapy Related Malignant NeoplasmTherapy Related Malignant TumorTherapy-Associated CancersTherapy-Related CancerThinnessTimeTrainingTranscription Factor Proto-OncogeneTranscription factor genesTreatment outcomeTreatment-Associated CancerTreatment-Related CancerVoluntary MuscleWasting DiseaseWasting SyndromeWeightWorkadiposityanti-cancer therapycancer associated cachexiacancer diagnosiscancer induced cachexiacancer therapycancer-associated muscle wastingcancer-directed therapycancer-induced muscle atrophycancer-induced muscle losscancer-induced muscle wastingcancer-related cachexiacarcinogenesiscareercareer developmentcorpulencedaily living functiondaily living functionalitydesigndesigningdevelopmentaldigestive tract microbiomedrivingdysbacteriosisdysbiosisdysbioticenteric microbial communityenteric microbiomeenteric microbiotaepidemiologicepidemiologicalexperiencefunctional abilityfunctional capacitygastrointestinal microbial floragastrointestinal microbiomegut communitygut dysbiosisgut floragut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomeimprovedintestinal biomeintestinal floraintestinal microbesintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloramalignancymicrobialmicrobial consortiamicrobial floramicrobial imbalancemicrobiomemicrobiotamicrofloramitochondrialmitochondrial dysfunctionmultiomicsmultiple omicsmultispecies consortiamuscle bulkmuscle formmuscle massneoplasm/cancernovelob/ob mouseoxidation reduction reactionpanomicspathophysiologyprotein degradationresectionskillssocial roletechnical skillstranscription factortumortumor-induced cachexiatumor-induced muscle wastingwasting conditionwasting disorderweights
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PROJECT SUMMARY
Research: At the time of cancer diagnosis, 40% - 60% of patients are overweight or obese. Despite this, there
is a dearth of literature on the impact of weight status on cancer-induced cachexia - the unintentional loss of lean
mass, which directly contributes to functional dependency, poor treatment outcomes, and decreased…
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