grant
Microbiome-driven immune changes and growth stunting in HIV-exposed uninfected children
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 11 May 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20250-11 years old0-4 weeks old7S Gamma GlobulinAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAddressAgeAntibodiesAntibody ResponseAutoregulationB blood cellsB cellB cellsB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBiologicalBirthBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBlood monocyteBreast FeedingBreast MilkBreast fedBreastfedBreastfeedingBreastmilkCaringCells Placenta-TissueCharacteristicsChildChild HealthChild YouthChildhoodChildren (0-21)ClinicalCommunicable DiseasesCommunicationDataDefectDevelopmentDiarrheaDietEarly InterventionEarly identificationEnrollmentEnteralEntericEnvironmental ExposureEpidemiologyFc ReceptorFecesFoodFunctional MetagenomicsGI microbiomeGeneralized GrowthGestationGoalsGrowthHIVHealthHomeostasisHuman Immunodeficiency VirusesHuman MilkHuman Mother's MilkIgAIgGImmuneImmune responseImmune systemImmunesImmunityImmunoglobulin AImmunoglobulin GImmunologyInfectionInfectious DiseasesInfectious DisorderInflammatoryInfrastructureInnate Immune ResponseInvestigatorsLAV-HTLV-IIILaboratoriesLinkLong-term cohortLongitudinal cohortLymphadenopathy-Associated VirusMammary Gland MilkMarrow monocyteMaternal ImmunityMaternally-Acquired ImmunityMeasuresMetadataMetagenomicsMicrobeMorbidityMorbidity - disease rateMother's MilkMothersNational Institutes of HealthNeonatalNewborn InfantNewbornsNormal PlacentomaNutritionNutritional statusOrganismOutcomeParturitionPathogenicityPathway interactionsPersonsPhysiological HomeostasisPlacentaPlacenta Embryonic TissuePlacentomePlasmaPlasma SerumPlayPredispositionPregnancyPregnant WomenProteobacteriaPublic HealthPurple BacteriaReceptor ProteinRecurrenceRecurrentReportingResearchResearch PersonnelResearchersResolutionReticuloendothelial System, Serum, PlasmaRiskSamplingSerologySerumShapesShort-Chain Fatty AcidsSourceSusceptibilitySystemT-CellsT-LymphocyteTimeTissue GrowthUgandaUmbilical CordUmbilical cord structureUnited States National Institutes of HealthVaccinationViralVirulenceVirus-HIVVolatile Fatty AcidsWorkactive followupagesanti-microbialantibody receptorantibody transferantimicrobialantiretroviral therapyantiretroviral treatmentbiobankbiologicbiorepositoryburden of diseaseburden of illnessco-morbidco-morbiditycohortcomorbiditydata pipelinedevelopmentaldiarrheal diseasediarrheal illnessdietsdigestive tract microbiomedisease burdendisease modeldisorder modelenrollenteric microbiomeepidemiologicepidemiologicalexpectant motherexpectant womenexpecting motherexpecting womenfecal samplefollow upfollow-upfollowed upfollowupgastrointestinal microbiomegut microbiomegut microbiome of infantgut-associated microbiomehigh riskhost responseimmune system responseimmunization strategyimmunoresponseimprovedimproved outcomeindividuals who are pregnantinfant gut microbiomeinfection recurrenceinnovateinnovationinnovativeintestinal biomeintestinal microbiomekidsliving systemmaternal milkmeta datametabolism measurementmetabolomicsmetabonomicsmicrobialmicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome interventionmicrobiome species compositionmicrobiome structuremicrobiome therapeuticsmicrobiome therapymicrobiome treatmentmicrobiome-based interventionmicrobiome-based therapeuticmicrobiome-based therapymicrobiome-based treatmentmonocytemortalityneonate gut microbiomenewborn childnewborn childrennewborn gut microbiomenovelontogenypathobiontpathogenpathwaypediatricpeerpeople who are pregnantpoor health outcomepregnant femalespregnant motherspregnant peoplepregnant populationsprospectivereceptorreceptor bindingreceptor boundrecurrent infectionrecurring infectionreduced health outcomeresolutionsspecies differencestoolstool samplestool specimenthose who are pregnantthymus derived lymphocytevaccination strategyvaccine responsevaccine responsivenessvaccine strategyvaccine-induced responsewomen who are pregnantworse health outcomeyoungster
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PROJECT SUMMARY
Despite increasing access to antiretroviral therapy (ART) in pregnancy, the >1 million children born annually to
pregnant people with HIV (PPHIV) who are HIV-exposed but uninfected (HEU) remain at >2-fold higher risk of
growth stunting and infectious morbidity than HIV-unexposed children. Though the origins of adverse HEU child…
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