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MGH- PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY202512-20 years old21+ years oldAbdominal DeliveryActive Follow-upAddressAdenomatous PolypsAdolescenceAdolescentAdolescent YouthAdultAdult HumanAgeAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAsiaAutomobile DrivingAutoregulationBiologic FactorBiologic ModelsBiologicalBiological FactorsBiological ModelsBirthBody TissuesBody Weight ChangesC sectionCancer CauseCancer EtiologyCancersCausalityCell BodyCellsCesareanCesarean sectionCessation of lifeChemicalsChemistryCohort EffectCollaborationsCollectionColorectal CancerColorectal NeoplasmsColorectal TumorsComputational BiologyConceptionsDataDeathDedicationsDevelopmentDiabetes MellitusDiagnosticDietDietary intakeDimensionsDisciplineDiseaseDisease OutcomeDisorderEarly identificationEcologic SystemsEcological SystemsEcosystemEnvironmental EpidemiologyEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorEpidemiologic DeterminantsEpidemiologic FactorsEpidemiologic ResearchEpidemiologic StudiesEpidemiological FactorsEpidemiological StudiesEpidemiologyEpidemiology ResearchEpithelial CellsEtOH drinkingEtOH useEthnic OriginEthnicityEtiologyEuropeExposure toFranceFrequenciesFutureFuture GenerationsGI microbiomeGeneration EffectGenerationsGenomicsGeographyGoalsHealthHomeostasisHumanHuman FigureHuman bodyImmunologyIncidenceIndividualIntakeJob LocationJob PlaceJob SettingJob SiteLarge Bowel TumorLarge Intestine NeoplasmLarge Intestine TumorLatin AmericaLesionLettersLife CycleLife Cycle StagesLinkLocationMalignant NeoplasmsMalignant TumorMeasurementMeasuresMediatingMetabolicMetabolic syndromeMexicanMexicoMindModel SystemModelingModern ManMolecularNatureNurses' Health StudyObesityOncogenesisParturitionPathway interactionsPatternPhysiologicPhysiologicalPhysiological HomeostasisPopulationPositionPositioning AttributePredispositionPrevalencePreventative interventionPreventative strategyPreventionPrevention strategyPreventive strategyProcessProspective StudiesRaceRacesRectal CancerRectal CarcinomaReportingReproducibilityReproducibility of FindingsReproducibility of ResultsResearchResearch ResourcesResolutionResourcesRiskRisk AssessmentRisk FactorsRoleS elementSightSulfurSulfur-Reducing BacteriaSurvey InstrumentSurveysSusceptibilityTechniquesTechnologyTerm BirthTestingTissuesTranslatingTumor PromotionUnhealthy DietVIT DValidationVariantVariationVisionVitamin DWeight ChangeWomanWorkWork LocationWork PlaceWork-SiteWorkplaceWorksiteactive followupadenomaadiposityadolescence (12-20)adult youthadulthoodage associatedage correlatedage dependentage linkedage relatedage specificagedagesalcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakeanti-cancer researchbinge alcohol consumptionbinge drinkingbiologicbirthing individualbirthing patientbirthing peoplecancer diagnosiscancer initiationcancer microenvironmentcancer preventioncancer progressioncancer researchcausationchromatin modificationcohortcolon cancer riskcolorectal cancer riskcolorectal neoplasiacomputer biologycorpulencedata diversitydesigndesigningdevelopmentaldiabetesdietarydietsdigestive tract microbiomedisease causationdiverse datadrinkingdrivingearly adulthoodearly colo-rectal cancerearly colorectal cancerearly life exposureearly onsetearly onset colo-rectal adenomaearly onset colo-rectal cancerearly onset colorectal adenomaearly onset colorectal canceremerging adultenteric microbiomeenvironmental riskepidemiologicepidemiologic investigationepidemiologicalepidemiology studyepigenomeepisodic drinkingethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol useexperimentexperimental researchexperimental studyexperimentsexposomefollow upfollow-upfollowed upfollowupfull-term birthfull-term newborngastrointestinal microbiomegenomic signaturegut microbiomegut-associated microbiomehigh riskimprintimprovedindexingindividual who gives birthinnovateinnovationinnovativeintervention for preventionintestinal biomeintestinal microbiomejuvenilejuvenile humanlarge bowel neoplasmlife courselife spanlife style interventionlifespanlifestyle interventionmalignancymenmicrobialmicrobiome sequencingmodel of animalneoplasm progressionneoplasm/cancerneoplastic progressionnovelobesity-promoting dietobesogenic Western-style dietobesogenic dietobesogenic high fat dietobesogenic western dietoffspringoffspring obesitypathwaypatient who gives birthpeople giving birthpeople who birthpeople who give birthpharmacologicpollutantpolypoid adenomapoor dietpopulation basedpreventpreventingprevention interventionpreventional intervention strategypreventive interventionpro-obesity dietprogenitor biologyprogenitor cell biologyracialracial backgroundracial originresolutionsrisk stratificationsmall moleculesocialsocial determinantssocial rolesociodeterminantstem and progenitor biologystem cell biologystratify risksugarsulfur metabolizing bacteriasweetened beverageteacherterm newborntumor initiationtumor microenvironmenttumor progressiontumorigenesisvalidationsvisual functionwork settingyoung adultyoung adult ageyoung adulthoodyoung colo-rectal canceryoung colorectal canceryoung onset colo-rectal canceryoung onset colorectal canceryounger age
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Description preview
ABSTRACT
Our vision is to unravel and ultimately reverse the intricate network of causal factors throughout the life course
that disrupts biological homeostasis to promote colorectal cancer (CRC) among individuals younger than age 50
years. Uniting leading scientific minds in early-onset colorectal cancer (EOCRC) research and complementary
fields,…
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