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Metabolomic interrogation of gut mechanosensing in Drosophila
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAddressAdenosineAdenosine ReceptorsAdultAdult HumanAgingAlimentary CanalAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaBiologic ModelsBiological ModelsBody TissuesBrainBrain Nervous SystemCancersCell AgingCell BodyCell Communication and SignalingCell SenescenceCell SignalingCellsCellular AgingCellular MechanotransductionCellular SenescenceCognitionDNA mutationDefectDegenerative Neurologic DisordersDetectionDietary FactorsDigestive TractDiseaseDisorderDrosophilaDrosophila genusDysplasiaEncephalonEnterocytesEnteroendocrine CellEpitheliumExhibitsExposure toFliesFoodGI Stem cellGI TractGastrointestinal TractGastrointestinal tract structureGeneralized GrowthGenerationsGeneticGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGoalsGrowthGut EpitheliumHealthImageImmuneImmunesImmunityIn SituIntermediary MetabolismIntracellular Communication and SignalingInvestigationIon ChannelIonic ChannelsLC/MSLabelLinkLipidsLysolecithinsLysophosphatidylcholinesMALD-MSMALDIMALDI-MSMalignant NeoplasmsMalignant TumorMammaliaMammalsMechanical Signal TransductionMechanosensory TransductionMediatingMembrane ChannelsMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismMethodsMidgutModel SystemModelingMolecularMutationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuropeptidesOrganism-Level ProcessOrganismal ProcessP1 PurinoceptorsPeristalsisPhysiologicPhysiologic ProcessesPhysiologicalPhysiological ProcessesPhysiologyPilot ProjectsPrimary Senile Degenerative DementiaProgenitor CellsPublicationsPublishingPurine ReceptorsPurinergic P1 ReceptorsPurinergic ReceptorsPurinesPurinoceptorReceptor ProteinReplicative SenescenceResolutionRoleScientific PublicationSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSiteSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSpectroscopy, Mass, Matrix-Assisted Laser Desorption-IonizationStretchingSystemTachykininTestingTimeTissue GrowthTissuesWorkabsorptionadulthoodagedaging associatedaging processaging relatedalimentary tractbiological signal transductioncell behaviorcell typecellular behaviorcohortdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdigestive canaldyscrasiafat metabolismflyfruit flygastrointestinal epitheliumgastrointestinal functiongastrointestinal stem cellgenome mutationgut progenitorgut stem cellimaginginnovateinnovationinnovativeinsightinterestintestinal progenitorintestinal stem cellslipid metabolismliquid chromatography mass spectrometrymalignancymatrix assisted laser desorption ionizationmechanical forcemechanosensingmechanotransductionmetabolism measurementmetabolomicsmetabonomicsmicrobialmodel organismmutantneoplasm/cancerneuralneurodegenerative illnessnovelnutrient absorptionontogenypilot studyprimary degenerative dementiaprogenitor cell proliferationprogenitor proliferationpublic health relevancereceptorreplicative agingresolutionsresponsesenile dementia of the Alzheimer typesensorshear stresssocial rolestem and progenitor cell proliferationstem cell proliferationstem cellssynergismtool
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Project description
Gut epithelium is the principal site in which neural, immune, microbial and dietary factors interact.
These multi-system interactions critically regulate whole-body physiology including metabolism,
immunity, and neurodegenerative diseases. Gut epithelium is exposed to a myriad of mechanical
forces that are generated by gut…
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