grant
Metabolic reprogramming of endothelial precursor cells in subretinal fibrosis
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 30 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ActinsActive Follow-upAdoptive TransferAfter CareAfter-TreatmentAftercareAgeAge related macular degenerationAge-Related MaculopathyAmino AcidsAreaBasal Transcription FactorBasal transcription factor genesBlindnessBlood VesselsBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBone-Derived Transforming Growth FactorCCN2CTGFCell BodyCell Communication and SignalingCell ComponentsCell SignalingCell StructureCell to Cell Communication and SignalingCell-Cell SignalingCellsCellular StructuresChimera ProteinChimeric ProteinsChoroidChoroid NeovascularizationChoroidal NeovascularizationCicatrixClinicalCollagenComplicationConditioned Culture MediaConditioned MediumDevelopmentDisciform macular degenerationDisciform senile macular retinal degenerationDiseaseDisorderEffector CellEndothelial CellsEndotheliumEpitheliumEventExperimental ModelsExpression SignatureExudative AMDExudative age-related macular degenerationEyeEyeballFibroblastsFibrosisFusion ProteinGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGlycolysisGlycolysis InhibitionGoalsGrowth AgentsGrowth FactorGrowth SubstancesHortega cellHumanIGF-binding protein-related protein-2IGFBP-8IGFBP-rP2ImmunofluorescenceImmunofluorescence ImmunologicImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroInterleukinsIntermediary MetabolismIntracellular Communication and SignalingInvoluntary MuscleKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLaser ElectromagneticLaser RadiationLaser injuryLasersLesionMacrophageMeasuresMediatingMesenchymalMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsMicrogliaMilk Growth FactorMitochondriaModelingModern ManMolecularMonitorMouse ProteinMuller gliaMuller's cellMurineMusMyeloid CellsMüller cellMüller gliaMφNeovascular AMDNeovascular age-related macular degenerationNull MouseOxidative PhosphorylationOxidative Phosphorylation PathwayPatientsPatternPlatelet Transforming Growth FactorProductionProliferatingPropertyProteins Growth FactorsPublishingRNA ExpressionReceptor GeneReceptor ProteinRecombinant InterleukinsRecombinant Transforming Growth FactorRecombinantsRetinaRoleScarsSightSignal TransductionSignal Transduction SystemsSignalingSmooth MuscleSourceSpatial DistributionStaining methodStainsStem Cell likeTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeutic EffectTherapeutic InterventionTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTreatment FactorVEGFVEGFsVLDL receptorVascular Endothelial Growth FactorsVimentinVisionVisual AcuityWet AMDWild Type Mouseactive followupage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophyagesaminoacidangiogenesisbiological signal transductioncell typeconnective tissue growth factorcytokinedamage to retinadevelopmentaldigitaleffective therapyeffective treatmentfisp12 proteinfollow upfollow-upfollowed upfollowupgene expression patterngene expression signaturegitter cellhuman tissueimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vitro testingin vivoinhibitorinsulin-like growth factor binding protein 8intercellular communicationintervention therapyintravitreal injectionlaser photocoagulationmesogliametabolism measurementmetabolomicsmetabonomicsmicroglial cellmicrogliocytemitochondrialmouse modelmurine modelnanostringneovascularneural inflammationneuroinflammationneuroinflammatorynovelperivascular glial cellpost treatmentprecursor cellpreferenceprogenitor capacityprogenitor cell likeprogenitor-likeprogramsprotein biomarkersprotein markersreceptorrecruitrepairrepairedresponseretinal damagescRNA sequencingscRNA-seqsenile macular diseasesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall molecular inhibitorsmall molecule inhibitorsocial rolestem cell characteristicsstem-likestemnesssuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscription factortranscriptional profiletranscriptional signaturetransdifferentiationvalidation studiesvascularvery low density lipoprotein receptorsvision lossvisual functionvisual losswet form of AMDwildtype mouse
Description preview
Therapeutic agents that target the vascular endothelial growth factor (VEGF) have achieved remarkable
success in patients with the neovascular form of age-related macular degeneration (nAMD). An emerging
clinical problem, however, is that many of the nAMD patients develop subretinal fibrosis (SRF) after receiving
anti-VEGF therapy. SRF can cause…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click