grant
Metabolic Modulation Suppresses Survival Signals in B-Cell Lymphoma
Organization SOUTH TEXAS VETERANS HEALTH CARE SYSTEMLocation SAN ANTONIO, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2030
VANIHUS FederalResearch GrantFY20262,4,D/2,4,5,T2-ketoglutarate2-oxoglutarateAdoptive TransferAgreementAmino AcidsAminotransferasesArmed Forces PersonnelAsiaAspartateAspartate AminotransferasesAspartate ApoaminotransferaseAspartate TransaminaseAssayAutoregulationB blood cellsB cellB cellsB lymphomaB-Cell LymphomasB-CellsB-LymphocytesB-cellBalkansBioassayBiochemical ReactionBiological AssayBiologyBiomassBlood CellsBranched-Chain Amino AcidsCancer BiologyCancersCatabolismCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCellular ExpansionCellular GrowthChemical ExposureClinicClinicalConsumptionD-GlucoseDLBCLDNA mutationDataDehydrogenasesDevelopmentDextroseDiagnosisDietary SupplementationDiffuse Large B-Cell LymphomaDoseDrug CombinationsEarly identificationEctopic ExpressionEffectivenessEnvironmentEnvironmental ToxinEnzymatic ReactionEnzyme GeneEnzymesExposure toFDA approvedFormulationGOT2GOT2 geneGeneralized GrowthGenerationsGenesGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGerminoblastic SarcomaGerminoblastomaGlnGlucoseGlucose Binding ProteinGlucose Transport ProteinGlucose TransporterGlutamate-Aspartate TransaminaseGlutamatesGlutamic-Oxaloacetic TransaminaseGlutamineGoalsGrowthHomeostasisHumanHuman ResourcesImmuno-ChemotherapyImmunochemotherapyIn VitroIncidenceInduction of ApoptosisInfectious AgentIntermediary MetabolismInterventionIntracellular Communication and SignalingIsoleucineIsotope LabelingKeto AcidsKetosuccinatesKinasesKnock-outKnockoutKnowledgeL-AspartateL-Aspartate-2-Oxoglutarate AminotransferaseL-GlutamateL-GlutamineL-ValineLeucineLinkLymphomaLymphoma cellMalignant CellMalignant LymphomaMalignant NeoplasmsMalignant TumorManpowerMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMetabolicMetabolic ProcessesMetabolismMethodologyMiceMice MammalsMilitaryMilitary PersonnelModalityModelingModern ManMurineMusMutationNitrogenOncogenicOxaloacetatesOxidoreductaseOxidoreductase GeneOxosuccinatesPenetrancePeripheral Blood CellPermeabilityPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPopulationPositionPositioning AttributePrimary NeoplasmPrimary TumorProcessProductionQ LevoglutamideQ. LevoglutamideReactionReductasesResearchReticulolymphosarcomaRiskRoleSignal TransductionSignal Transduction SystemsSignalingSomatic MutationStarvationStrains Cell LinesSupplementationTestingTherapeuticTimeTissue GrowthToxic Environmental AgentsToxic Environmental SubstancesToxic effectToxicitiesTransaminasesTranslationsTransphosphorylasesTumor BurdenTumor CellTumor LoadTumor Suppressor ProteinsValineVeteransViet NamVietnamagent orangeaging preventionalpha ketoglutarateaminoacidanti aginganti geronicantiaginganticancer activitybiological signal transductionbranched amino acidsburn pitcancer cellcancer typecell growthchemo-immuno therapychemoimmunotherapyclinical predictorsclinical translationclinically translatablecultured cell linedevelopmentaldiet supplementationenvironmental toxicantgenome mutationglucose uptakeglutamatergicglutamic aspartic transaminasehuman modelimprovedin vitro testingin vivoin vivo Modelinfectious organisminhibitorinnovateinnovationinnovativeinsightketoacidlarge cell Diffuse non-Hodgkin's lymphomamTOR Inhibitormalignancymilitary populationmilitary servicemodel of humanmutantneoplasm/cancerneoplastic cellnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyoperationoperationspersonnelprevent age relatedprevent agingrational designsmall molecular inhibitorsmall molecule inhibitorsocial rolesomatic variantsuppress agingtransaminase Atranslationtranslational opportunitiestranslational potentialtreatment strategytumortumor growthtumor suppressorα-ketoglutarateα-oxoglutarateαKG
Description preview
Significance to VA
: Metabolic remodeling is integral to cancer biology. The discovery of somatic mutations
in genes encoding metabolic enzymes provided insights into how subverting metabolism promotes
cancer. These studies also uncovered opportunities for metabolic interventions with anti-cancer activity.
Building on this idea, we postulated…
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