grant
Metabolic mechanisms of cognitive decline in aging and AD mediated by inflammatory PGE2 signaling
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AD dementiaAD modelAD pathologyAdventitial CellAge associated cognitive deficitAge associated cognitive dysfunctionAge related memory declineAge related memory deficitAge related memory impairmentAge related pathologiesAge-associated cognitive declineAge-related cognitive declineAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAmmon HornAstrocytesAstrocytusAstrogliaBBB functionBenign senescent forgetfulnessBioenergeticsBiologicalBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood monocyteBlood-Brain BarrierBody TissuesBrainBrain InflammationBrain Nervous SystemCell BodyCell Communication and SignalingCell ReprogrammingCell SignalingCellsCellular Immune FunctionCerebral endotheliumCerebrovascular systemCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCornu AmmonisD-GlucoseDataDevelopmentDextroseDinoprostoneDisturbance in cognitionEncephalitisEncephalonEndotheliumEnergy ExpenditureEnergy MetabolismFoot ProcessGene TranscriptionGeneticGenetic TranscriptionGlucoseHemato-Encephalic BarrierHippocampusHortega cellHumanImmuneImmune PlasmaImmune responseImmunesImmunologic FactorsImmunological FactorsImpaired cognitionInflammationInflammatoryInflammatory ResponseIntermediary MetabolismIntracellular Communication and SignalingInvestigationLinkLipidsMacrophageMarrow monocyteMediatingMemoryMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMicrogliaMitochondriaModelingModern ManMurineMusMyelogenousMyeloidMyeloid CellsMφNerve CellsNerve UnitNeural CellNeurocyteNeuronsOrganOutcomePGE2PGE2 alphaPGE2alphaPathway interactionsPedicelPericapillary CellPericytesPeripheralPerivascular CellPhenocopyPre-Clinical ModelPreclinical ModelsPrimary Senile Degenerative DementiaProstaglandin E2Prostaglandin E2 alphaProstaglandin E2alphaRNA ExpressionReceptor ProteinRejuvenationResearchRespirationRiboTagRoleRouget CellsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingTestingTissuesTranscriptTranscriptionTransmissionage associatedage associated cognitive impairmentage associated memory declineage associated memory deficitage associated pathologiesage correlatedage dependentage dependent pathologiesage induced pathologiesage linkedage relatedage related cognitive deficitage related cognitive dysfunctionage related cognitive impairmentage related memory dysfunctionage reversalage specificage-associated memory impairmentage-induced cognitive declineage-related decline in cognitionage-related decline in cognitive functionagedaged miceaged mouseaging associated pathologiesaging dependent pathologiesaging induced pathologiesaging pathologiesaging related cognitive declineaging related pathologiesaging reversalalleviate age relatedalleviate agingalzheimer modelameliorating agingantagonismantagonistastrocytic gliabiologicbiological signal transductionblood vessels in the brainblood-brain barrier functionbloodbrain barrierbloodbrain barrier functionbrain blood vesselsbrain endothelial cellbrain endotheliumbrain microvascular endothelial cellbrain vascular endothelial cellbrain vasculaturecapillary bedcell agecellular agecellular reprogrammingcerebral blood vesselcerebral endothelial cellcerebral microvascular endothelial cellcerebral vascular endothelial cellcerebral vasculaturecerebrovascular vesselscerebrovasculaturecognitive dysfunctioncognitive functioncognitive losscortical endotheliumcounter age relatedcounter agingcounteract age relatedcounteract agingdeclining cognitive functions with agingdevelopmentalelderly micefunctional improvementgitter cellhippocampalhost responseimmune functionimmune system responseimmunologic substanceimmunological substanceimmunoresponseimprove functionimprovedimproved functional outcomesin vivomesogliametabolism measurementmetabolomicsmetabonomicsmicroglial cellmicrogliocytemitochondrialmonocytemouse modelmurine modelmutantnerve cell metabolismneuron cell metabolismneuron metabolismneuronalneuronal cell metabolismneuronal metabolismold micepathwayperivascular glial cellpre-clinicalpreclinicalpreventpreventingprimary degenerative dementiareceptorrespiratory mechanismresponsereverse agereverse agingreverse aging effectsreversible agingsenile dementia of the Alzheimer typesocial rolesystemic inflammationsystemic inflammatory responsetranscriptomicstranslational studytransmission process
Description preview
Metabolic mechanisms of cognitive decline in aging and AD mediated by inflammatory PGE2 signaling
Project Summary
Aging is characterized by the development of maladaptive immune responses that promote cognitive decline
and Alzheimer’s disease (AD). We recently identified the inflammatory lipid messenger prostaglandin E2
(PGE2), signaling through…
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