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Metabolic control of cue reactivity during alcohol withdrawal

Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Dec 2022Deadline 30 Apr 2025 ⚠️
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAcetatesAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcohol dependenceAlcohol withdrawal syndromeAlcoholsAmericanAmerican dietAminalonAminaloneAmino AcidsAnteriorAutomobile DrivingAutoregulationBehaviorBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBioenergeticsBrainBrain Nervous SystemBrain regionCessation of lifeChronicCognitionCognitiveConditioning TherapyCuesDeathDevelopmentDiet ModificationDietary ModificationsDopamineDorsalDrug Metabolic DetoxicationDrug Metabolic DetoxificationEncephalonEtOH drinkingEtOH useGABAGlnGlutamatesGlutamineGoalsHomeostasisHydroxytyramineIndividualIntermediary MetabolismInterventionL-GlutamateL-GlutamineMR SpectroscopyMagnetic Resonance SpectroscopyMaintenanceMeasuresMediationMental disordersMental health disordersMetabolicMetabolic ControlMetabolic Drug DetoxicationsMetabolic ProcessesMetabolismMetabolism of Toxic AgentsMissionModelingNIAAANational Institute on Alcohol Abuse and AlcoholismNegotiatingNegotiationNerve Transmitter SubstancesNeurotransmittersParticipantPatientsPersonsPhysiological HomeostasisPopulationPsychiatric DiseasePsychiatric DisorderQ LevoglutamideQ. LevoglutamideReactionRelapseResearchRewardsRoleScanningSpecific qualifier valueSpecifiedStructureSystemTestingTimeUnited StatesVentral StriatumWithdrawalWithdrawal Symptomalcohol addictionalcohol cravingalcohol cuealcohol dependencyalcohol dependentalcohol ingestionalcohol intakealcohol product usealcohol related cuealcohol responsealcohol usealcohol use disorderalcohol withdrawalalcoholic beverage consumptionalcoholic drink intakeaminoacidbehavior interventionbehavior measurementbehavioral interventionbehavioral measurebehavioral measurementbrain controlbrain metabolismburden of diseaseburden of illnesschronic EtOH drinkingchronic alcohol consumptionchronic alcohol drinkingchronic alcohol ingestionchronic alcohol usechronic ethanol consumptionchronic ethanol drinkingchronic ethanol ingestioncingulate cortexcognitive reappraisalcognitive regulationcontrol theorycravingcue reactivitydeprivationdetoxificationdevelopmentaldiet alterationdietary alterationdisease burdendrinkingdrivingethanol consumptionethanol cravingethanol cueethanol drinkingethanol ingestionethanol intakeethanol product useethanol responseethanol useethanol use disorderethanol withdrawalfMRI scanfunctional MRI scanfunctional magnetic resonance imaging scangamma-Aminobutyric Acidglucose metabolismglutamatergicinsightketo dietketogenicketogenic dietketogenticmental illnessmulti-modal datamulti-modal datasetsmultimodal datamultimodal datasetsneuralneural circuitneural circuitryneural mechanismneurocircuitryneuromechanismnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentprematureprematuritypsychiatric illnesspsychological disorderresponseresponse to alcoholresponse to ethanolsocial rolesynaptic circuitsynaptic circuitrytherapeutic agent developmenttherapeutic developmenttoolwithdrawal from alcoholγ-Aminobutyric Acid

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Description preview

PROJECT SUMMARY
Alcohol use disorder (AUD) is one of the most prevalent psychiatric disorders in the United States. Chronic

alcohol consumption in individuals with AUD is associated with lowered glucose metabolism and increased

acetate metabolism in the brain. Following abrupt cessation of alcohol consumption, sudden decreases in

acetate may cause…

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