grant
Metabolic basis for oligo-vascular interactions in white matter development and injury
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY20260-11 years oldAPLNAPLN geneAbruptio PlacentaeAffectAgonistAsphyxia NeonatorumAxonBlood VesselsBlood flowBrainBrain Hypoxia-IschemiaBrain Nervous SystemBrain VascularCell Communication and SignalingCell SignalingCerebral HypoxiaCerebral Tissue HypoxiaCerebral endotheliumCerebrovascular CirculationChildChild YouthChildhood strokeChildren (0-21)CirculationCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalD-GlucoseDataDefectDevelopmentDextroseDisturbance in cognitionEncephalonEndothelial CellsEndotheliumFetal Growth RestrictionFetal Growth RetardationGeneticGlucoseHumanHypoglycemiaIUGRImpaired cognitionIn VitroInfantInjuryIntracellular Communication and SignalingIntranasal AdministrationIntranasal Drug AdministrationIntrauterine Growth RetardationKnowledgeLigandsMaintenanceMediatingMetabolicMetabolic PathwayMiceMice MammalsMitochondriaModelingModern ManMolecularMotorMurineMusMyelinNatural regenerationNeonatalNeonatal asphyxia-induced brain injuryNeonatal hypoxic brain injuryNeural DevelopmentO elementO2 elementOL myelinationOligoOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOligonucleotidesOutcomeOxygenPathway interactionsPeptidesPhenotypePremature BirthPremature Separation of PlacentaPrematurely deliveringPreterm BirthProcessProgenitor CellsProteomicsReceptor ProteinReceptor SignalingRegenerationRegulationResearch SpecimenRoleSignal TransductionSignal Transduction SystemsSignalingSpecimenTerm BirthTestingTherapeuticTransgenic ModelVascularizationWorkangiogenesisapelinapelin-13biological signal transductionbirth asphyxiabirth complicationsblood flow in brainbrain blood circulationbrain blood flowbrain endothelial cellbrain endotheliumbrain microvascular endothelial cellbrain vascular endothelial cellcerebral blood flowcerebral circulationcerebral endothelial cellcerebral microvascular endothelial cellcerebral vascularcerebral vascular endothelial cellcerebro-vascularcerebrocirculationcerebrovascularcerebrovascular blood flowcognitive defectscognitive dysfunctioncognitive losscortical endotheliumdelivery complicationsdevelopmentalfetalfull-term birthfull-term newbornglucose uptakehypoglycemichypoglycemic episodeshypoxia/ischemiahypoxic ischemic encephalopathyhypoxic ischemic injuryimpaired fetal growthin vivoinjuriesinsightintra-uterine growth restrictionintra-uterine growth retardationintrauterine growth restrictionkidsmitochondrialmotor deficitmotor impairmentmovement impairmentmovement limitationmutantmyelinationneonatal HIEneonatal asphyxianeonatal brain hypoxia-ischemianeonatal hypoxia-ischemianeonatal hypoxic-ischemic brain damageneonatal hypoxic-ischemic brain injuryneonatal hypoxic-ischemic encephalopathyneonatal miceneurodevelopmentneuroprotectionneuroprotectivenoveloligodendrocyte myelinationoligospathwaypediatric strokeperinatal asphyxiapharmacologicplacental abruptionpost-natal asphyxiapremature childbirthpremature deliveryprenatal growth disorderpreterm deliveryreceptorreceptor expressionregeneraterepairrepairedresilienceresilientsocial rolestem cellssubstantia albaterm newborntransgenic traitvascularwhite matterwhite matter injuryyoungster
Description preview
Project Summary
Neonatal white matter injury (NWMI) is a major cause of motor and cognitive abnormalities in infants born pre-
term, as well as in term births with complications such as intrauterine growth restriction, placental abruption, and
birth asphyxia. Cerebral hypoxia and altered fetal circulation cause myelination defects in these…
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