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Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer

Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 May 2021Deadline 1 Sept 2025 ⚠️
NIHUS FederalResearch GrantFY2025ATP Citrate (pro-3S)-LyaseATP Citrate (pro-S)-LyaseATP Citrate LyaseATP citrate pro3s lyaseATP-Dependent Citrate LyaseAcetyl CoAAcetyl Coenzyme AAcetylationAddressAffectCCNECCNE1CCNE1 geneCancer GenesCancer PatientCancer-Promoting GeneCancersCell BodyCell Cycle ProgressionCell NucleusCellsChromatinCitrate Cleavage EnzymeClinicalCyclin ECyclin-E1CytoplasmD-GlucoseDNA DamageDNA Damage RepairDNA InjuryDNA RepairDNA Repair EnzymesDataDependenceDevelopmentDextroseDiseaseDisorderDrugsEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFallopian TubesFutureGene TranscriptionGenetic TranscriptionGlucoseGoalsHistone AcetylaseHistone AcetylationHistonesHomologous Recombinational RepairHumanIntermediary MetabolismKnowledgeLinkMalignant CellMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMammalian OviductsMediatingMedicationMetabolicMetabolic ProcessesMetabolismModelingModern ManMolecularNucleusOncogenesOncogenesisOncogenicOvarianOvary CancerPARP InhibitorPARP-1 inhibitorPARPiPathway interactionsPatientsPharmaceutical PreparationsPhenotypePoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) polymerase 1 inhibitorProliferatingProteinsPublishingRNA ExpressionRecombination RepairRelaxationResearchResistanceRoleS-acetate Coenzyme ASalpinxSerousTestingTherapeuticTranscriptionTransforming GenesUnscheduled DNA SynthesisUterine Tubescancer cellcancer typecitrate pro3s lyaseclinical relevanceclinically relevantdevelopmentaldrug/agentepigeneticallyepigenomehistone acetyltransferasehomologous recombinationhomologous recombination deficiencyhomologous recombination repair deficiencyimprovedinhibitorinhibitor druginhibitor therapeuticinhibitor therapyinsightmalignancyneoplasm/cancernew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetovarian canceroverexpressoverexpressionoviductpathwaypatient populationprogramsrecombinational repairrecruitreplication stressresistantresponseresponse to therapyresponse to treatmentsocial rolespatial and temporalspatial temporalspatiotemporalstandard of caresynergismsynthetic lethal interactionsynthetic lethalitytherapeutic outcometherapeutic responsetherapy outcometherapy responsetreatment responsetreatment responsivenesstreatment strategytumortumorigenesistumorigenic

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Project Summary/Abstract
The ultimate goal of this mPI proposal is to address a fundamental gap in knowledge on the role of acetyl-CoA
metabolic reprogramming in regulating cyclin E-high ovarian cancer DNA damage response, transformation, and
response to therapy. The results from these studies could have a significant impact on the treatment of…

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Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer — UNIVERSITY OF PITTSBURGH AT PITTSBURGH | UNITED | Dev Procure