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Membrane Spanning and Subcellular Trafficking Mechanisms of a Viral Capsid Protein- Lessons from a Master Cell Biologist

Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 1 Feb 2024Deadline 14 Oct 2025 โš ๏ธ
NIHUS FederalResearch GrantFY2025ADAM10 proteinBacterial ToxinsC-terminalCapsid Protein L2Capsid ProteinsCell BodyCell Communication and SignalingCell SignalingCellsCellular biologyCoat ProteinsElementsEndosomesFamilyGolgiGolgi ApparatusGolgi ComplexHPVHPV L2HPV L2 oncogene viral capsid proteinHuman Papilloma VirusHuman PapillomavirusInfectionInfectious Human Wart VirusIntracellular Communication and SignalingIonsKnowledgeL2 viral capsid proteinMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMinorOrganismPathway interactionsPenetrationPeptidesProcessProtein TraffickingProteinsReceptosomesRoleSignal TransductionSignal Transduction SystemsSignalingSurface ProteinsTM DomainTransmembrane DomainTransmembrane RegionViralViral Coat ProteinsViral Outer Coat ProteinVirusWorkbiological signal transductioncell biologyendosome membranegamma secretasegamma secretase complexhuman papilloma virus L2human papillomavirus L2insightlenslensesliving systemmembrane structurepathwayprotein transportretrograde transportsocial rolesorting nexinstraffickingvirologywart virusฮณ-secretase

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PROJECT SUMMARY / ABSTRACT
Throughout the course of coevolution within their host organisms, viruses have evolved to
become masters of the cell- manipulating and exploiting cellular signaling, transport, and
trafficking pathways. Studies of basic virology offer the prospect of illuminating cellular biology
through the lens of a natural cellโ€ฆ

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